小柯机器人

英国爱丁堡大学Sarah R. Walmsley研究小组发现，中性粒细胞通过糖异生和糖原生产来为有效的免疫反应供能。2020年12月10日，《细胞—代谢》杂志在线发表了这项成果。

通过使用放射性通量测定法和U-13C葡萄糖、谷氨酰胺和丙酮酸的LC-MS示踪，研究人员观察到中性粒细胞需要通过糖异生和糖原生成来产生细胞内的糖原储藏，从而有效存活并杀死细菌。这些代谢适应是动态的，在LPS攻击或海拔导致的缺氧后，糖原贮藏量净增加。患有慢性阻塞性肺疾病患者的中性粒细胞减少了糖原循环，并导致功能受损。因此，嗜中性粒细胞的代谢特化可能是疾病病理的原因，并可能用于靶向治疗。

据了解，中性粒细胞可以在受伤和受感染的组织中工作并存活，但这些组织中的氧气和代谢底物有限。

附：英文原文

Title: Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Author: Pranvera Sadiku, Joseph A. Willson, Eilise M. Ryan, David Sammut, Patricia Coelho, Emily R. Watts, Robert Grecian, Jason M. Young, Martin Bewley, Simone Arienti, Ananda S. Mirchandani, Manuel A. Sanchez Garcia, Tyler Morrison, Ailing Zhang, Leila Reyes, Tobias Griessler, Privjyot Jheeta, Gordon G. Paterson, Christopher J. Graham, John P. Thomson, Kenneth Baillie, A.A. Roger Thompson, Jessie-May Morgan, Abel Acosta-Sanchez, Veronica M. Dardé, Jordi Duran, Joan J. Guinovart, Gio Rodriguez-Blanco, Alex Von Kriegsheim, Richard R. Meehan, Massimiliano Mazzone, David H. Dockrell, Bart Ghesquiere, Peter Carmeliet, Moira K.B. Whyte, Sarah R. Walmsley

Issue&Volume: 2020-12-10

Abstract: Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils require the generation of intracellular glycogen stores by gluconeogenesis and glycogenesis for effective survival and bacterial killing. These metabolic adaptations are dynamic, with net increases in glycogen stores observed following LPS challenge or altitude-induced hypoxia. Neutrophils from patients with chronic obstructive pulmonary disease have reduced glycogen cycling, resulting in impaired function. Metabolic specialization of neutrophils may therefore underpin disease pathology and allow selective therapeutic targeting.

DOI: 10.1016/j.cmet.2020.11.016

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30651-3

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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