英国皇家德比医院Graham Johnson团队对《小乔治的神奇魔药》中的药物进行了毒理学分析。2020年12月10日，该研究发表在《英国医学杂志》上。
为了分析罗尔德·达尔的书《小乔治的神奇魔药》中描述的同名药草的治疗效果和毒性，研究组对两个文学形象，即小乔治和他的姥姥，进行了一项文献评论。研究组根据国家毒物信息服务的毒物数据库ToxBase中列出的成分，检查了每种成分的临床和毒性作用。
结果发现文中的魔药含有34种成分。在ToxBase上发现的最常见的毒性作用是恶心和呕吐（16种成分，占47％）。潜在威胁生命的影响与13种（38%）成分有关，包括中枢神经系统抑郁、肾损伤、惊厥、心脏毒性和粘膜侵蚀。书中描述的初始疗效是准确的，但后来偏离了最可能的临床结果（死亡）。
尽管达尔因其《小乔治的神奇魔药》中药物成分毒理学的最初准确性而备受赞扬，但总体疗效将是致命的、灾难性的生理崩溃。应该鼓励儿童进行科学探索和实验，在任何人服用之前，必须检查药用成分的潜在毒性。
附：英文原文
Title: Toxicological analysis of George’s marvellous medicine: literature review
Author: Graham Johnson, Patrick Davies
Issue&Volume: 2020/12/10
Abstract:
Objective To analyse the therapeutic effects and toxicity of the eponymous concoction described in Roald Dahl’s book George’s Marvellous Medicine.
Design Literature review.
Setting Two literature loving households in England.
Participants George Kranky and grandma Kranky.
Main outcome measures Clinical and toxic effects of the individual ingredients checked against those listed in ToxBase, the National Poisons Information Service’s poisons database.
Results The medicine contained 34 ingredients. The most common toxic effect identified on ToxBase was nausea and vomiting (16 ingredients, 47%). Potentially life threatening effects were associated with 13 (38%) ingredients, including depression of the central nervous system, kidney injury, convulsions, cardiac toxicity, and mucosal erosion. The effects described in the book were accurate initially but then diverted from the most likely clinical outcome (death).
Conclusions Although Dahl ought to be applauded for his initial accuracy about the toxicology of the ingredients in George’s marvellous medicine, the overall effect would be fatal catastrophic physiological collapse. Scientific exploration and experimentation should be encouraged in children, although any medicinal ingredients need to be checked for potential toxicity before being administered—to grandmas or anyone else.
DOI: 10.1136/bmj.m4467
Source: https://www.bmj.com/content/371/bmj.m4467
BMJ-British Medical Journal:《英国医学杂志》，创刊于1840年。隶属于BMJ出版集团，最新IF：93.333
官方网址：http://www.bmj.com/
投稿链接：https://mc.manuscriptcentral.com/bmj
本期文章：《英国医学杂志》：Online/在线发表
