小柯机器人

美国杜克大学Stefano Di Talia、Kenneth D. Poss等研究人员合作发现，一系列的Erk活性波动调控成骨细胞的再生。2021年1月6日，《自然》杂志在线发表了这项成果。

研究人员发现，Erk活性的节律行波参与控制斑马鱼鳞片（毫米级保护性身体盔甲）再生中时空性骨骼生长。研究人员发现，Erk活性从中心源以扩大的同心环形式穿过成骨细胞群体，从而诱导组织生长的环状模式。使用理论和实验分析的组合，研究人员表明Erk活性作为触发波来传播，从而能够在两天内到达全部鱼鳞，并且波的产生频率控制着鱼鳞的再生速度。

此外，同步、全组织激活的周期性Erk诱导会削弱组织的生长，这表明波散布的Erk激活是再生的关键。这些发现揭示了触发波作为调节细胞行为并指导组织再生过程的调控策略。

据了解，再生是一系列复杂的事件，可将组织恢复到其原始大小和形状。适当的形态发生所需的细胞动态协调受到了身体部位再生尺寸大小的挑战。生化途径中的反馈机制可以在远距离上提供有效的交流，但是在组织再生过程中它们如何调节生长仍未解决。

附：英文原文

Title: Control of osteoblast regeneration by a train of Erk activity waves

Author: Alessandro De Simone, Maya N. Evanitsky, Luke Hayden, Ben D. Cox, Julia Wang, Valerie A. Tornini, Jianhong Ou, Anna Chao, Kenneth D. Poss, Stefano Di Talia

Issue&Volume: 2021-01-06

Abstract: Regeneration is a complex chain of events that restores a tissue to its original size and shape. The tissue-wide coordination of cellular dynamics that is needed for proper morphogenesis is challenged by the large dimensions of regenerating body parts. Feedback mechanisms in biochemical pathways can provide effective communication across great distances1,2,3,4,5, but how they might regulate growth during tissue regeneration is unresolved6,7. Here we report that rhythmic travelling waves of Erk activity control the growth of bone in time and space in regenerating zebrafish scales, millimetre-sized discs of protective body armour. We find that waves of Erk activity travel across the osteoblast population as expanding concentric rings that are broadcast from a central source, inducing ring-like patterns of tissue growth. Using a combination of theoretical and experimental analyses, we show that Erk activity propagates as excitable trigger waves that are able to traverse the entire scale in approximately two days and that the frequency of wave generation controls the rate of scale regeneration. Furthermore, the periodic induction of synchronous, tissue-wide activation of Erk in place of travelling waves impairs tissue growth, which indicates that wave-distributed Erk activation is key to regeneration. Our findings reveal trigger waves as a regulatory strategy to coordinate cell behaviour and instruct tissue form during regeneration.

DOI: 10.1038/s41586-020-03085-8

Source: https://www.nature.com/articles/s41586-020-03085-8

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html