小柯机器人

哈尔滨医科大学孙长颢等研究人员合作发现，等热量的高脂饮食可延长雄性大鼠和果蝇的寿命。相关论文于2021年1月12日在线发表于国际学术期刊《细胞—代谢》。

研究人员发现，与正常饮食相比，等热量的中等高脂肪饮食（IHF）通过下调FFA合成代谢和上调分解代谢途径来降低血清和多个组织中的游离脂肪酸（FFA）谱，从而显著延长了大鼠和果蝇的寿命。蛋白质组学分析在大鼠中鉴定出PPRC1是被IHF显著上调了近2倍的关键蛋白，而在FFA中，只有棕榈酸（PA）与PPRC1的表达呈强负相关。

使用PPRC1转基因RNAi/过表达果蝇和体外实验，研究人员证明IHF可以显著降低PA，从而可以通过PPARG上调PPRC1，进而改善氧化应激和炎症反应，并延长寿命。

据了解，饮食脂肪对健康的影响一直是营养领域最令人困扰的问题之一。很少有动物研究通过控制能量摄入来检查高脂饮食对寿命的影响。 

附：英文原文

Title: An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

Author: Dan Shi, TianShu Han, Xia Chu, Huimin Lu, Xue Yang, TianQi Zi, YanHe Zhao, XinYue Wang, ZhiPeng Liu, JingQi Ruan, Xin Liu, Hua Ning, MaoQing Wang, Zhen Tian, Wei Wei, Yue Sun, YinLing Li, Rui Guo, Yu Wang, Fan Ling, Yue Guan, Da Shen, YuCun Niu, Ying Li, ChangHao Sun

Issue&Volume: 2021-01-12

Abstract: The health effect of dietary fat has been one of the most vexing issues in the fieldof nutrition. Few animal studies have examined the impact of high-fat diets on lifespanby controlling energy intake. In this study, we found that compared to a normal diet,an isocaloric moderately high-fat diet (IHF) significantly prolonged lifespan by decreasingthe profiles of free fatty acids (FFAs) in serum and multiple tissues via downregulatingFFA anabolism and upregulating catabolism pathways in rats and flies. Proteomics analysisin rats identified PPRC1 as a key protein that was significantly upregulated by nearly2-fold by IHF, and among the FFAs, only palmitic acid (PA) was robustly and negativelyassociated with the expression of PPRC1. Using PPRC1 transgenic RNAi/overexpressionflies and in vitro experiments, we demonstrated that IHF significantly reduced PA, which could upregulatePPRC1 through PPARG, resulting in improvements in oxidative stress and inflammationand prolonging the lifespan.

DOI: 10.1016/j.cmet.2020.12.017

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30672-0

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