小柯机器人

Title: Functional characterization of the dural sinuses as a neuroimmune interface

Author: Justin Rustenhoven, Antoine Drieu, Tornike Mamuladze, Kalil Alves de Lima, Taitea Dykstra, Morgan Wall, Zachary Papadopoulos, Mitsuhiro Kanamori, Andrea Francesca Salvador, Wendy Baker, Mackenzie Lemieux, Sandro Da Mesquita, Andrea Cugurra, James Fitzpatrick, Sanja Sviben, Ross Kossina, Peter Bayguinov, Reid R. Townsend, Qiang Zhang, Petra Erdmann-Gilmore, Igor Smirnov, Maria-Beatriz Lopes, Jasmin Herz, Jonathan Kipnis

Issue&Volume: 2021-01-27

Abstract: Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmuneinteractions play an active role in diverse neurological disorders. However, the precisemechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomicalsites where peripheral adaptive immunity can sample CNS-derived antigens and the cellularand molecular mediators orchestrating this surveillance. Here, we demonstrate thatCNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the duralsinuses, are captured by local antigen-presenting cells, and are presented to patrollingT cells. This surveillance is enabled by endothelial and mural cells forming the sinusstromal niche. T cell recognition of CSF-derived antigens at this site promoted tissueresident phenotypes and effector functions within the dural meninges. These findingshighlight the critical role of dural sinuses as a neuroimmune interface, where brainantigens are surveyed under steady-state conditions, and shed light on age-relateddysfunction and neuroinflammatory attack in animal models of multiple sclerosis.

DOI: 10.1016/j.cell.2020.12.040

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31762-1