小柯机器人

南非发现突刺糖蛋白突变的新型SARS-CoV-2变种
2021-03-11 16:07

2021年3月9日,南非夸祖鲁-纳塔尔大学Tulio de Oliveira小组在《自然》杂志发表论文,报道发现突刺糖蛋白突变的新型SARS-CoV-2变种。

研究人员报道了一种新的SARS-CoV-2谱系(501Y.V2),其特征在于刺突蛋白中有8个谱系定义突变,其中3个位于受体结合域的重要残基(K417N、E484K和N501Y)上,并可能具有功能意义。该谱系是在南非东开普省沿海严重受灾的大都会地区纳尔逊·曼德拉湾(Nelson Mandela Bay)的第一波流行病爆发后发现的。

这个谱系迅速传播,并在数周之内在东开普省、西开普省和夸祖鲁-纳塔尔省占据主导地位。尽管尚未确定突变的全部重要性,但基因组数据显示在多个地方出现快速增加并替代其他谱系,并表明该谱系与选择优势相关,最可能的原因是传播性的增加或免疫逃逸。 

据悉,在世界许多地方,持续不断的SARS-CoV-2传播正在为病毒的进化创造条件。

附:英文原文

Title: Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

Author: Houriiyah Tegally, Eduan Wilkinson, Marta Giovanetti, Arash Iranzadeh, Vagner Fonseca, Jennifer Giandhari, Deelan Doolabh, Sureshnee Pillay, Emmanuel James San, Nokukhanya Msomi, Koleka Mlisana, Anne von Gottberg, Sibongile Walaza, Mushal Allam, Arshad Ismail, Thabo Mohale, Allison J. Glass, Susan Engelbrecht, Gert Van Zyl, Wolfgang Preiser, Francesco Petruccione, Alex Sigal, Diana Hardie, Gert Marais, Marvin Hsiao, Stephen Korsman, Mary-Ann Davies, Lynn Tyers, Innocent Mudau, Denis York, Caroline Maslo, Dominique Goedhals, Shareef Abrahams, Oluwakemi Laguda-Akingba, Arghavan Alisoltani-Dehkordi, Adam Godzik, Constantinos Kurt Wibmer, Bryan Trevor Sewell, Jos Loureno, Luiz Carlos Junior Alcantara, Sergei L. Kosakovsky Pond, Steven Weaver, Darren Martin, Richard J. Lessells, Jinal N. Bhiman, Carolyn Williamson, Tulio de Oliveira

Issue&Volume: 2021-03-09

Abstract: Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for significant virus evolution1,2. Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance3–5. This lineage was identified in South Africa after the first epidemic wave in a severely affected metropolitan area, Nelson Mandela Bay, located on the coast of the Eastern Cape Province. This lineage spread rapidly, becoming dominant in the Eastern Cape, Western Cape and KwaZulu-Natal Provinces within weeks. Whilst the full significance of the mutations is yet to be determined, the genomic data, showing the rapid expansion and displacement of other lineages in multiple regions, suggest that this lineage is associated with a selection advantage, most plausibly as a result of increased transmissibility or immune escape6–8.

DOI: 10.1038/s41586-021-03402-9

Source: https://www.nature.com/articles/s41586-021-03402-9

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

分享到:

0