小柯机器人

英国东英吉利大学Jonathan D. G. Jones和Pingtao Ding研究组合作取得最新进展。他们发现细胞表面和细胞内受体相互促进增强植物免疫力。2021年3月10日出版的《自然》杂志发表了这项成果。

通过激活细胞内受体而不诱导表面受体介导的免疫，他们分析了拟南芥中这两个不同的免疫系统之间的相互作用。表面受体对病原体的识别会激活多种蛋白激酶和NADPH氧化酶，并且他们发现细胞内受体主要通过几种机制增加蛋白的丰度来增强这些蛋白的激活。同样，依赖于细胞内受体的超敏反应通过表面受体的激活而大大增强。仅这两个免疫系统的激活不足以对细菌病原体丁香假单胞菌进行有效的抵抗。

因此，植物中细胞表面和细胞内受体激活的免疫途径相互促进，从而增强了对病原体的防御能力。这些发现重塑了人们对植物免疫力的理解，对作物改良具有广泛的意义

据介绍，植物免疫系统涉及检测细胞间病原体来源分子的细胞表面受体，以及检测到在植物细胞内起作用的病原体分泌效应蛋白后激活免疫力的细胞内受体。表面受体介导的免疫已被广泛研究，但是在缺乏表面受体介导的免疫情况下，很少研究细胞内受体介导的免疫。此外，人们对这两种免疫途径之间的相互作用了解甚少。

附：英文原文

Title: Mutual potentiation of plant immunity by cell-surface and intracellular receptors

Author: Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, Jonathan D. G. Jones

Issue&Volume: 2021-03-10

Abstract: The plant immune system involves cell-surface receptors that detect intercellular pathogen-derived molecules, and intracellular receptors that activate immunity upon detection of pathogen-secreted effector proteins that act inside the plant cell. Immunity mediated by surface receptors has been extensively studied1, but that mediated by intracellular receptors has rarely been investigated in the absence of surface-receptor-mediated immunity. Furthermore, interactions between these two immune pathways are poorly understood. Here, by activating intracellular receptors without inducing surface-receptor-mediated immunity, we analyse interactions between these two distinct immune systems in Arabidopsis. Pathogen recognition by surface receptors activates multiple protein kinases and NADPH oxidases, and we find that intracellular receptors primarily potentiate the activation of these proteins by increasing their abundance through several mechanisms. Likewise, the hypersensitive response that depends on intracellular receptors is strongly enhanced by the activation of surface receptors. Activation of either immune system alone is insufficient to provide effective resistance against the bacterial pathogen Pseudomonas syringae. Thus, immune pathways activated by cell-surface and intracellular receptors in plants mutually potentiate to activate strong defences against pathogens. These findings reshape our understanding of plant immunity and have broad implications for crop improvement.

DOI: 10.1038/s41586-021-03315-7

Source: https://www.nature.com/articles/s41586-021-03315-7

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html