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美国范德比尔特大学Cynthia A. Reinhart-King研究组总结机械反应性代谢在癌细胞迁移和转移中的作用。这一综述论文于2021年4月28日在线发表在国际学术期刊《细胞—代谢》上。

研究人员表示，改变的组织力学和新陈代谢正在逐渐用来定义癌症的特征，这些特征不仅影响增殖，而且影响迁移。在机械和空间异质性微环境中迁移时，新陈代谢的变化使细胞能够响应不断变化的能量需求动态地调节能量的产生和生物能。来自细胞外基质的物理信号影响机械信号通路、细胞力学和细胞骨架结构，从而改变代谢酶的表达和功能。在癌症中，改变的机械感知和代谢重编程能够促进新陈代谢的可塑性和高能量产生，同时细胞迁移和转移。

研究人员讨论了机械响应代谢在调节细胞迁移和支持转移中的作用，以及治疗性靶向癌症代谢来阻止运动和潜在转移的潜力。 

附：英文原文

Title: Mechanoresponsive metabolism in cancer cell migration and metastasis

Author: Matthew R. Zanotelli, Jian Zhang, Cynthia A. Reinhart-King

Issue&Volume: 2021-04-28

Abstract: Altered tissue mechanics and metabolism are defining characteristics of cancer thatimpact not only proliferation but also migration. While migrating through a mechanicallyand spatially heterogeneous microenvironment, changes in metabolism allow cells todynamically tune energy generation and bioenergetics in response to fluctuating energyneeds. Physical cues from the extracellular matrix influence mechanosignaling pathways,cell mechanics, and cytoskeletal architecture to alter presentation and function ofmetabolic enzymes. In cancer, altered mechanosensing and metabolic reprogramming supportsmetabolic plasticity and high energy production while cells migrate and metastasize.Here, we discuss the role of mechanoresponsive metabolism in regulating cell migrationand supporting metastasis as well as the potential of therapeutically targeting cancermetabolism to block motility and potentially metastasis.

DOI: 10.1016/j.cmet.2021.04.002

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00168-6

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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