小柯机器人

美国哥伦比亚大学Joshua Jacobs团队揭示人类海马和内嗅皮层的相位进动。这一研究成果于2021年5月11日在线发表在国际学术期刊《细胞》上。

研究人员表示，知道我们在哪里，曾经去过哪里以及我们要去哪里对许多行为（包括导航和记忆）都是至关重要的。这种能力背后的一种潜在的神经元机制是相位进动，其中空间调节的神经元通过在局部网络theta振荡的逐渐较早的阶段激活来表示位置序列。基于对啮齿动物的研究，研究人员假设相差进动可能是代表学习和记忆顺序事件的一般神经模式。

通过记录人类单个神经元在空间导航过程中的活动，研究人员表明，在人类海马体和内嗅皮层中，空间调整的神经元表现出相差。此外，除了位置的神经表示之外，研究人员还显示了与特定目标状态相关的相位进动证据。因此，这个发现将theta相位进动扩展到人类，并表明该现象对于空间和非空间信息的神经表示都具有广泛的功能。

附：英文原文

Title: Phase precession in the human hippocampus and entorhinal cortex

Author: Salman E. Qasim, Itzhak Fried, Joshua Jacobs

Issue&Volume: 2021-05-11

Abstract: Knowing where we are, where we have been, and where we are going is critical to manybehaviors, including navigation and memory. One potential neuronal mechanism underlyingthis ability is phase precession, in which spatially tuned neurons represent sequencesof positions by activating at progressively earlier phases of local network thetaoscillations. Based on studies in rodents, researchers have hypothesized that phaseprecession may be a general neural pattern for representing sequential events forlearning and memory. By recording human single-neuron activity during spatial navigation,we show that spatially tuned neurons in the human hippocampus and entorhinal cortexexhibit phase precession. Furthermore, beyond the neural representation of locations,we show evidence for phase precession related to specific goal states. Our findingsthus extend theta phase precession to humans and suggest that this phenomenon hasa broad functional role for the neural representation of both spatial and non-spatialinformation.

DOI: 10.1016/j.cell.2021.04.017

Source: https://www.cell.com/cell/fulltext/S0092-8674(21)00496-7