小柯机器人

美国加州大学旧金山分校Valerie M. Weaver团队发现，粘附介导的机械信号引起线粒体低毒兴奋效应。相关论文于2021年5月20日在线发表于国际学术期刊《细胞—代谢》。

研究人员证明，细胞能够感知细胞外基质的物理特性并激活线粒体应激反应，该反应通过溶质载体家族9成员A1依赖性离子交换和热休克因子1依赖性转录来适应性地调节线粒体功能。总体而言，这些数据表明，粘附介导的机械信号转导在衰老和癌症中观察到的线粒体功能改变中可能发挥了重要作用。

据介绍，线粒体通过产生维持生命所需的能量和执行程序性细胞死亡所需的信号来控制真核细胞的命运。已知生化环境会影响线粒体功能，并导致功能异常的线粒体表型与癌症和衰老发病率有关。但是，在癌变和衰老的组织中，细胞外基质的物理特性也发生了变化。

附：英文原文

Title: Adhesion-mediated mechanosignaling forces mitohormesis

Author: Kevin M. Tharp, Ryo Higuchi-Sanabria, Greg A. Timblin, Breanna Ford, Carlos Garzon-Coral, Catherine Schneider, Jonathon M. Muncie, Connor Stashko, Joseph R. Daniele, Andrew S. Moore, Phillip A. Frankino, Stefan Homentcovschi, Sagar S. Manoli, Hao Shao, Alicia L. Richards, Kuei-Ho Chen, Johanna ten Hoeve, Gregory M. Ku, Marc Hellerstein, Daniel K. Nomura, Karou Saijo, Jason Gestwicki, Alexander R. Dunn, Nevan J. Krogan, Danielle L. Swaney, Andrew Dillin, Valerie M. Weaver

Issue&Volume: 2021-05-20

Abstract: Mitochondria control eukaryotic cell fate by producing the energy needed to supportlife and the signals required to execute programed cell death. The biochemical milieuis known to affect mitochondrial function and contribute to the dysfunctional mitochondrialphenotypes implicated in cancer and the morbidities of aging. However, the physicalcharacteristics of the extracellular matrix are also altered in cancerous and agingtissues. Here, we demonstrate that cells sense the physical properties of the extracellularmatrix and activate a mitochondrial stress response that adaptively tunes mitochondrialfunction via solute carrier family 9 member A1-dependent ion exchange and heat shockfactor 1-dependent transcription. Overall, our data indicate that adhesion-mediatedmechanosignaling may play an unappreciated role in the altered mitochondrial functionsobserved in aging and cancer.

DOI: 10.1016/j.cmet.2021.04.017

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00183-2

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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