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研究总结果蝇模型在代谢领域的应用潜力
2021-06-20 15:52

英国帝国理工学院Irene Miguel-Aliaga等研究人员合作总结果蝇模型在代谢领域的应用潜力。2021年6月16日,《细胞—代谢》杂志在线发表了这项成果。

研究人员总结了果蝇研究如何能够用于解决三个广泛领域中长期存在的问题:通过荷尔蒙或神经机制控制代谢、肠道内感受和进食的器官间信号传递,以及性二态性代谢和生理学的细胞和信号基础,以及如何解决这些发现与人类(病理)生理学有关。综合生理学和相关方法在果蝇中对代谢问题的应用正在扩大,并将成为发现的引擎,有望揭示人类疾病和健康生理平衡的代谢范式特征。

据悉,使用果蝇和其他无脊椎动物系统来剖析新陈代谢调控机制的应用迅速增长。新的生理学检测方法与果蝇中的遗传工具共同为提出新问题或剖析代谢和疾病遗传学中的经典问题提供了强大的平台。在多个例子中,这些发现利用了哺乳动物系统中尚不具备的实验优势。

附:英文原文

Title: Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

Author: Seung K. Kim, Deborah D. Tsao, Greg S.B. Suh, Irene Miguel-Aliaga

Issue&Volume: 2021-06-16

Abstract: There has been rapid growth in the use of Drosophila and other invertebrate systems to dissect mechanisms governing metabolism. New assaysand approaches to physiology have aligned with superlative genetic tools in fruitflies to provide a powerful platform for posing new questions, or dissecting classicalproblems in metabolism and disease genetics. In multiple examples, these discoveriesexploit experimental advantages as-yet unavailable in mammalian systems. Here, weillustrate how fly studies have addressed long-standing questions in three broad areas—inter-organsignaling through hormonal or neural mechanisms governing metabolism, intestinal interoceptionand feeding, and the cellular and signaling basis of sexually dimorphic metabolismand physiology—and how these findings relate to human (patho)physiology. The imaginativeapplication of integrative physiology and related approaches in flies to questionsin metabolism is expanding, and will be an engine of discovery, revealing paradigmaticfeatures of metabolism underlying human diseases and physiological equipoise in health.

DOI: 10.1016/j.cmet.2021.05.018

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00269-2

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx


本期文章:《细胞—代谢》:Online/在线发表

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