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Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride
2021-06-22 10:07

美国哥伦比亚大学Jack R. Norton研究小组取得一项新突破。他们的最新研究提出了铑氢化物催化C=C键的高选择性氢化反应。这一研究成果发表在2021年6月18日出版的国际学术期刊《美国化学会杂志》上。

在温和条件下(室温,80psi H2) Cp*Rh(2-(2-吡啶基)苯基)H催化α,β不饱和羰基化合物中的C=C键选择性氢化,包括β位置上有大位阻取代基的天然产物前体和具有一系列附加官能团的底物。它也催化许多孤立双键的氢化。

机理研究表明,没有自由基中间体参与,催化剂似乎是均相的,因此为类似的加氢过程提供了重要的补充。

附:英文原文

Title: Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride

Author: Yiting Gu, Jack R. Norton, Farbod Salahi, Vladislav G. Lisnyak, Zhiyao Zhou, Scott A. Snyder

Issue&Volume: June 18, 2021

Abstract: Under mild conditions (room temperature, 80 psi of H2) Cp*Rh(2-(2-pyridyl)phenyl)H catalyzes the selective hydrogenation of the C═C bond in α,β-unsaturated carbonyl compounds, including natural product precursors with bulky substituents in the β position and substrates possessing an array of additional functional groups. It also catalyzes the hydrogenation of many isolated double bonds. Mechanistic studies reveal that no radical intermediates are involved, and the catalyst appears to be homogeneous, thereby affording important complementarity to existing protocols for similar hydrogenation processes.

DOI: 10.1021/jacs.1c04683

Source: https://pubs.acs.org/doi/10.1021/jacs.1c04683

 

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