小柯机器人

近日，同济大学Rui Zeng等研究人员合作发现，益生菌L.casei Zhang可减缓急性和慢性肾脏疾病的进展。该项研究成果于2021年7月15日在线发表在《细胞—代谢》杂志上。

研究人员表明，口服益生菌Lactobacillus casei Zhang（L. casei Zhang）可以纠正双侧肾脏缺血再灌注（I/R）引起的肠道微生物菌群失调，减轻肾脏损伤，并延缓其向慢性肾脏疾病（CKD）的发展。L. casei Zhang提高了血清和肾脏中短链脂肪酸（SCFA）和烟酰胺的水平，导致肾脏炎症和肾小管上皮细胞的损伤减少。研究人员还进行了一项为期1年的口服L. casei Zhang的安慰剂对照研究（中国临床试验注册中心，ChiCTR-INR-17013952），该研究的耐受性良好，减缓了3-5期CKD患者的肾脏功能下降。

这些结果表明，口服L. casei Zhang通过改变SCFA和烟酰胺代谢可作为一种潜在的治疗方法，并可以减轻肾脏损伤，减缓肾脏衰退的进展。

据悉，肠道微生物失调与急性或慢性肾脏疾病（CKD）之间的关系仍不清楚。

附：英文原文

Title: The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

Author: Han Zhu, Chujin Cao, Zhongcai Wu, Heping Zhang, Zhihong Sun, Meng Wang, Huzi Xu, Zhi Zhao, Yuxi Wang, Guangchang Pei, Qian Yang, Fengming Zhu, Juan Yang, Xuan Deng, Yu Hong, Yinzheng Li, Jie Sun, Fan Zhu, Mengxia Shi, Kun Qian, Ting Ye, Xuezhi Zuo, Fenfei Zhao, Jing Guo, Gang Xu, Ying Yao, Rui Zeng

Issue&Volume: 2021-07-15

Abstract: The relationship between gut microbial dysbiosis and acute or chronic kidney disease(CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis,alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serumand kidney, resulting in reduced renal inflammation and damage to renal tubular epithelialcells. We also performed a 1-year phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clinical trial registry, ChiCTR-INR-17013952), which was well toleratedand slowed the decline of kidney function in individuals with stage 3–5 CKD. Theseresults show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigatekidney injury and slow the progression of renal decline.

DOI: 10.1016/j.cmet.2021.06.014

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00284-9

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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