小柯机器人

美国国立衰老研究所Rafael de Cabo小组揭示空腹血糖作为死亡率预测因素的可行性。相关论文于2021年9月10日在线发表在《细胞—代谢》杂志上。

研究人员比较了小鼠、非人灵长类动物和人类在整个生命周期中的空腹血糖、体重和脂肪量的纵向轨迹、变化率和死亡风险，并发现这三个物种的体重和脂肪轨迹相似。相比之下，小鼠的空腹血糖在生命晚期有所下降，但在非人类灵长类动物和人类的生命周期中有所上升。较高的血糖与小鼠的低死亡率有关，但在非人类灵长类动物和人类中的死亡率较高，这为将与年龄相关的代谢变化从小鼠转化到人类提供了一个前车之鉴。

据了解，衰老导致了葡萄糖平衡、体重和脂肪的显著变化，这被认为是人类健康和生存的良好预测因素。目前缺乏直接证据表明这些与年龄相关的代谢改变在动物模型中被重现，这阻碍了开发和测试干预措施的进展。

附：英文原文

Title: Fasting blood glucose as a predictor of mortality: Lost in translation

Author: Dushani L. Palliyaguru, Eric J. Shiroma, John K. Nam, Eleonora Duregon, Camila Vieira Ligo Teixeira, Nathan L. Price, Michel Bernier, Simonetta Camandola, Kelli L. Vaughan, Ricki J. Colman, Andrew Deighan, Ron Korstanje, Luanne L. Peters, Stephanie L. Dickinson, Keisuke Ejima, Eleanor M. Simonsick, Lenore J. Launer, Chee W. Chia, Josephine Egan, David B. Allison, Gary A. Churchill, Rozalyn M. Anderson, Luigi Ferrucci, Julie A. Mattison, Rafael de Cabo

Issue&Volume: 2021-09-10

Abstract: Aging leads to profound changes in glucose homeostasis, weight, and adiposity, whichare considered good predictors of health and survival in humans. Direct evidence thatthese age-associated metabolic alterations are recapitulated in animal models is lacking,impeding progress to develop and test interventions that delay the onset of metabolicdysfunction and promote healthy aging and longevity. We compared longitudinal trajectories,rates of change, and mortality risks of fasting blood glucose, body weight, and fatmass in mice, nonhuman primates, and humans throughout their lifespans and found similartrajectories of body weight and fat in the three species. In contrast, fasting bloodglucose decreased late in life in mice but increased over the lifespan of nonhumanprimates and humans. Higher glucose was associated with lower mortality in mice buthigher mortality in nonhuman primates and humans, providing a cautionary tale fortranslating age-associated metabolic changes from mice to humans.

DOI: 10.1016/j.cmet.2021.08.013

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00376-4

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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