南京工业大学陈苏团队开发了基于相转化的螺旋微纤维微流体制造方法用于多功能人造腹部皮肤。2021年9月10日出版的《德国应用化学》杂志发表了这项成果。
微流体纺丝技术（MST）将微流体与化学反应结合起来，在构建各向异性的高级微纤维，特别是螺旋微纤维方面引起了人们极大的兴趣。然而，现有的努力受到材料选择的限制，限制了它们的应用。
该文中，研究人员提出了一种新的基于相转化的微流控纺丝（PIMS）方法来生产螺旋状微纤维。该方法经历了物理化学相转化过程，能够有效地制造强（拉伸应力超过25 MPa）、可拉伸、柔性和生物相容性的螺旋超细纤维。螺旋状超细纤维可用于制造双向拉伸的人工腹部皮肤，防止切口疝的形成，促进伤口愈合而不粘连。
该研究不仅提供了一种设计螺旋状超细纤维的通用方法，而且为人造皮肤提供了新的见解。
附：英文原文
Title: A Phase Inversion-Based Microfluidic Fabrication of Helical Microfibers towards Versatile Artificial Abdominal Skin
Author: Ji-Dong Liu, Xiang-Yun Du, Su Chen
Issue&Volume: 2021-09-10
Abstract: Microfluidic spinning technology (MST), incorporating microfluidics with chemical reactions, has fastened considerable interests in constructing anisotropic advanced microfibers, especially helical microfibers. However, subsistent efforts suffer from the limited material choices, restricting their applications. Here, a new phase inversion-based microfluidic spinning (PIMS) method is proposed for producing helical microfibers. This method undergoes a physicochemical phase inversion process, which is capable of efficiently manufacturing strong (tensile stress of more than 25 MPa), stretchable, flexible and biocompatible helical microfibers. The helical microfibers can be used to fabricate bi-oriented stretchable artificial abdominal skin, preventing incisional hernia formation and promoting the wound healing without conglutination. This research not only offers a universal approach to design helical microfibers, but also provides a new insight into artificial skins.
DOI: 10.1002/anie.202110888
Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202110888
