天津大学吴水林团队设计了二维MOF光动力离子治疗法治疗牙周炎
传统的外科干预和抗生素治疗对慢性病（包括由多种口腔病原体引起的牙周炎）效果不佳，甚至无效，这些慢性病通常会导致组织的渐进性破坏，甚至牙齿脱落和系统性疾病。
该文中，研究人员通过加入聚乙二醇基质来设计包含原子层Fe2O3修饰的二维卟啉金属-有机骨架（2D MOF）纳米片的软膏。经过原子层沉积表面工程后，由于金属-连接体桥联单元的协同效应、丰富的活性中心和良好的光收集网络导致的较低的吸附能和更多的电荷转移量，2D MOF异质界面的光催化活性增强。该生物相容性和生物可降解的2D MOF异质结构通过活性氧物种和释放离子的协同作用，对多种口腔病原体（牙龈卟啉单胞菌、核梭杆菌和金黄色葡萄球菌）具有广谱抗菌活性（99.87±0.09%、99.57±0.21%和99.03±0.24%）。
该光动力离子疗法由于具有快速抗菌活性、减轻炎症和改善血管生成而显示出优于临床牙周炎治疗的疗效。
附：英文原文
Title: 2D MOF Periodontitis Photodynamic Ion Therapy
Author: Jun Li, Shuang Song, Jiashen Meng, Lei Tan, Xiangmei Liu, Yufeng Zheng, Zhaoyang Li, Kelvin Wai Kwok Yeung, Zhenduo Cui, Yanqin Liang, Shengli Zhu, Xingcai Zhang, Shuilin Wu
Issue&Volume: September 13, 2021
Abstract: Traditional surgical intervention and antibiotic treatment are poor and even invalid for chronic diseases including periodontitis induced by diverse oral pathogens, which often causes progressive destruction of tissues, even tooth loss, and systemic diseases. Herein, an ointment comprising atomic-layer Fe2O3-modified two-dimensional porphyrinic metal–organic framework (2D MOF) nanosheets is designed by incorporating a polyethylene glycol matrix. After the atomic layer deposition surface engineering, the enhanced photocatalytic activity of the 2D MOF heterointerface results from lower adsorption energy and more charge transfer amounts due to the synergistic effect of metal–linker bridging units, abundant active sites, and an excellent light-harvesting network. This biocompatible and biodegradable 2D MOF-based heterostructure exhibits broad-spectrum antimicrobial activity (99.87 ± 0.09%, 99.57 ± 0.21%, and 99.03 ± 0.24%) against diverse oral pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Staphylococcus aureus) by the synergistic effect of reactive oxygen species and released ions. This photodynamic ion therapy exhibits a superior therapeutic effect to the reported clinical periodontitis treatment owing to rapid antibacterial activity, alleviative inflammation, and improved angiogenesis.
DOI: 10.1021/jacs.1c07875
Source: https://pubs.acs.org/doi/10.1021/jacs.1c07875
