小柯机器人

美国哥伦比亚大学Ira Tabas课题组发现，胞葬作用诱导巨噬细胞增殖来帮助解决组织损伤。相关论文于2021年11月15日在线发表在《细胞—代谢》杂志上。

Title: Efferocytosis induces macrophage proliferation to help resolve tissue injury

Author: Brennan D. Gerlach, Patrick B. Ampomah, Arif Yurdagul, Chuang Liu, Max C. Lauring, Xiaobo Wang, Canan Kasikara, Na Kong, Jinjun Shi, Wei Tao, Ira Tabas

Issue&Volume: 2021-11-15

Abstract: Apoptotic cell clearance by macrophages (efferocytosis) promotes resolution signalingpathways, which can be triggered by molecules derived from the phagolysosomal degradationof apoptotic cells. We show here that nucleotides derived from the hydrolysis of apoptoticcell DNA by phagolysosomal DNase2a activate a DNAPKcsmTORC2/Rictor pathway thatincreases Myc to promote non-inflammatory macrophage proliferation. Efferocytosis-inducedproliferation expands the pool of resolving macrophages in vitro and in mice, including zymosan-induced peritonitis, dexamethasone-induced thymocyteapoptosis, and atherosclerosis regression. In the dexamethasone-thymus model, hematopoieticRictor deletion blocked efferocytosing macrophage proliferation, apoptotic cell clearance,and tissue resolution. In atherosclerosis regression, silencing macrophage Rictoror DNase2a blocked efferocyte proliferation, apoptotic cell clearance, and plaquestabilization. In view of previous work showing that other types of apoptotic cellcargo can promote resolution in individual efferocytosing macrophages, the findingshere suggest that signaling-triggered apoptotic cell-derived nucleotides can amplifythis benefit by increasing the number of these macrophages.

DOI: 10.1016/j.cmet.2021.10.015

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00527-1

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