小柯机器人

美国圣路易斯华盛顿大学Ilya E. Monosov、Takaya Ogasawara等研究人员合作发现一条灵长类中寻求新奇的神经回路。2021年12月13日，《自然—神经科学》杂志在线发表了这一最新研究成果。

据悉，灵长类动物通过探索视觉对象与世界互动；它们寻找机会观看新奇的对象，即使这些对象没有外在的奖励价值。大脑如何控制这种寻求新奇的行为尚不清楚。

附：英文原文

Title: A primate temporal cortex–zona incerta pathway for novelty seeking

Author: Ogasawara, Takaya, Sogukpinar, Fatih, Zhang, Kaining, Feng, Yang-Yang, Pai, Julia, Jezzini, Ahmad, Monosov, Ilya E.

Issue&Volume: 2021-12-13

Abstract: Primates interact with the world by exploring visual objects; they seek opportunities to view novel objects even when these have no extrinsic reward value. How the brain controls this novelty seeking is unknown. Here we show that novelty seeking in monkeys is regulated by the zona incerta (ZI). As monkeys made eye movements to familiar objects to trigger an opportunity to view novel objects, many ZI neurons were preferentially activated by predictions of novel objects before the gaze shift. Low-intensity ZI stimulation facilitated gaze shifts, whereas ZI inactivation reduced novelty seeking. ZI-dependent novelty seeking was not regulated by neurons in the lateral habenula or by many dopamine neurons in the substantia nigra, traditionally associated with reward seeking. But the anterior ventral medial temporal cortex, an area important for object vision and memory, was a prominent source of novelty predictions. These data uncover a functional pathway in the primate brain that regulates novelty seeking.

DOI: 10.1038/s41593-021-00950-1

Source: https://www.nature.com/articles/s41593-021-00950-1

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex