小柯机器人

近日，美国普林斯顿大学H. Sebastian Seung、Mala Murthy等研究人员合作开发出用于全脑连接组学分析的在线社区。相关论文于2021年12月23日在线发表在《自然—方法学》杂志上。

研究人员报道了FlyWire，一个用于校对黑腹果蝇大脑神经回路的在线社区，并解释了它的计算和社区结构是如何组织起来以扩展到全脑连接组学的。基于浏览器的三维交互式分割，通过协作编辑空间分块的supervoxel图，可以将校对工作分配给几乎位于世界任何地方的个人。编辑历史中的信息可以通过程序访问，用于各种用途，如估计校对的准确性或建立激励系统。一个开放的社区可以通过招募更多的参与者来加速校对，并通过要求信息共享来加速科学发现。研究人员展示了FlyWire如何通过重建和分析机械感觉神经元的连接组实现回路分析。

据介绍，由于自动图像采集和分析的进步，具有10万个或更多神经元的全脑连接体即将问世。由于涉及到大量的数据，全脑自动重建的校对将需要大量人力投入。

附：英文原文

Title: FlyWire: online community for whole-brain connectomics

Author: Dorkenwald, Sven, McKellar, Claire E., Macrina, Thomas, Kemnitz, Nico, Lee, Kisuk, Lu, Ran, Wu, Jingpeng, Popovych, Sergiy, Mitchell, Eric, Nehoran, Barak, Jia, Zhen, Bae, J. Alexander, Mu, Shang, Ih, Dodam, Castro, Manuel, Ogedengbe, Oluwaseun, Halageri, Akhilesh, Kuehner, Kai, Sterling, Amy R., Ashwood, Zoe, Zung, Jonathan, Brittain, Derrick, Collman, Forrest, Schneider-Mizell, Casey, Jordan, Chris, Silversmith, William, Baker, Christa, Deutsch, David, Encarnacion-Rivera, Lucas, Kumar, Sandeep, Burke, Austin, Bland, Doug, Gager, Jay, Hebditch, James, Koolman, Selden, Moore, Merlin, Morejohn, Sarah, Silverman, Ben, Willie, Kyle, Willie, Ryan, Yu, Szi-chieh, Murthy, Mala, Seung, H. Sebastian

Issue&Volume: 2021-12-23

Abstract: Due to advances in automated image acquisition and analysis, whole-brain connectomes with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated reconstructions will require many person-years of effort, due to the huge volumes of data involved. Here we present FlyWire, an online community for proofreading neural circuits in a Drosophila melanogaster brain and explain how its computational and social structures are organized to scale up to whole-brain connectomics. Browser-based three-dimensional interactive segmentation by collaborative editing of a spatially chunked supervoxel graph makes it possible to distribute proofreading to individuals located virtually anywhere in the world. Information in the edit history is programmatically accessible for a variety of uses such as estimating proofreading accuracy or building incentive systems. An open community accelerates proofreading by recruiting more participants and accelerates scientific discovery by requiring information sharing. We demonstrate how FlyWire enables circuit analysis by reconstructing and analyzing the connectome of mechanosensory neurons. FlyWire is an online community and a platform for proofreading electron microscopy-based connectome data of the Drosophila brain.

DOI: 10.1038/s41592-021-01330-0

Source: https://www.nature.com/articles/s41592-021-01330-0

Nature Methods：《自然—方法学》，创刊于2004年。隶属于施普林格·自然出版集团，最新IF：47.99
官方网址：https://www.nature.com/nmeth/
投稿链接：https://mts-nmeth.nature.com/cgi-bin/main.plex