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孟德尔随机分析揭示血液代谢物和肠道微生物组之间的因果关系
2022-01-05 14:22

深圳华大生命科学研究院张涛、贾慧珏等研究人员合作利用孟德尔随机分析揭示血液代谢物和肠道微生物组之间的因果关系。这一研究成果于2022年1月3日在线发表在国际学术期刊《自然—遗传学》上。

研究人员对3432名中国人的全基因组、全元基因组、人体测量和血液代谢性状数据进行了双向孟德尔随机化分析。研究人员确定了肠道微生物组和血液代谢物之间的58个因果关系,并重复了其中的43个。粪便中Oscillibacter和Alistipes的相对丰度增加与甘油三酯浓度下降有因果关系。相反,血液中的代谢物如谷氨酸似乎减少了粪便中的Oxalobacter,而变形菌(Proteobacteria)的成员则受到代谢物如5-甲基四氢叶酸、丙氨酸、谷氨酸和硒的影响。

利用日本生物银行的数据进行双样本孟德尔随机化,部分证实了甘油三酯和尿酸的结果,还为已公布的癌症和心血管疾病的粪便细菌标记物提供了因果关系的支持。这项研究说明了人类遗传信息的价值,有助于优先考虑肠道微生物特征的机理和临床研究。

据介绍,肠道微生物组与各种生理状态有关,但关于因果关系的争议仍未解决。

附:英文原文

Title: Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Author: Liu, Xiaomin, Tong, Xin, Zou, Yuanqiang, Lin, Xiaoqian, Zhao, Hui, Tian, Liu, Jie, Zhuye, Wang, Qi, Zhang, Zhe, Lu, Haorong, Xiao, Liang, Qiu, Xuemei, Zi, Jin, Wang, Rong, Xu, Xun, Yang, Huanming, Wang, Jian, Zong, Yang, Liu, Weibin, Hou, Yong, Zhu, Shida, Jia, Huijue, Zhang, Tao

Issue&Volume: 2022-01-03

Abstract: The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood metabolic trait data. We identified 58 causal relationships between the gut microbiome and blood metabolites, and replicated 43 of them. Increased relative abundances of fecal Oscillibacter and Alistipes were causally linked to decreased triglyceride concentration. Conversely, blood metabolites such as glutamic acid appeared to decrease fecal Oxalobacter, and members of Proteobacteria were influenced by metabolites such as 5-methyltetrahydrofolic acid, alanine, glutamate and selenium. Two-sample Mendelian randomization with data from Biobank Japan partly corroborated results with triglyceride and with uric acid, and also provided causal support for published fecal bacterial markers for cancer and cardiovascular diseases. This study illustrates the value of human genetic information to help prioritize gut microbial features for mechanistic and clinical studies. Bidirectional Mendelian randomization analyses in 3,432 Chinese individuals identify putative causal relationships between the gut microbiome and blood metabolite levels.

DOI: 10.1038/s41588-021-00968-y

Source: https://www.nature.com/articles/s41588-021-00968-y

Nature Genetics:《自然—遗传学》,创刊于1992年。隶属于施普林格·自然出版集团,最新IF:41.307
官方网址:https://www.nature.com/ng/
投稿链接:https://mts-ng.nature.com/cgi-bin/main.plex


本期文章:《自然—遗传学》:Online/在线发表

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