小柯机器人

美国罗格斯新泽西州医学院Jason S. Weinstein和美国耶鲁大学医学院Joe Craft团队共同合作取得重要工作进展，他们发现病毒感染中表达Tbet和CD11c的B细胞的发育需要生发中心外的T滤泡辅助细胞。该研究成果于2022年1月27日在线发表于《免疫学》杂志上。

在这里，研究人员鉴定了Tbet⁺CD11c⁺B细胞亚群的发育需求。在急性感染中，滤泡辅助性T细胞(T follicular helper，Tfh)，通过近端递送帮助促进Tbet⁺CD11c⁺ B细胞的生成。Tbet⁺CD11c⁺ B细胞先于生发中心(GC)形成，表现出与GC B细胞不同的表型和转录谱。命运追踪显示，大多数Tbet⁺CD11c⁺B细胞的发生与GC进入和细胞内Bcl6表达无关。Tbet⁺CD11c⁺和GC B细胞显示较少的特征重叠，表明它们来自不同的发育途径。

随着感染的消退，Tbet⁺CD11c⁺ B细胞定位到脾脏的边缘区域，依赖于整合素 LFA-1 和 VLA-4，形成一个竞争性记忆亚群，有助于抗体的产生，和再次病原体侵染时GC的功能发挥。因此，Tbet⁺CD11c⁺ B细胞包含一个独立于GC的记忆亚群，能够产生快速而稳定的回忆反应。

据了解，Tbet⁺CD11c⁺ B细胞在1型病原体侵袭、衰老和自身免疫过程中产生。

附：英文原文

Title: Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers

Author: Wenzhi Song, Olivia Q. Antao, Emily Condiff, Gina M. Sanchez, Irene Chernova, Krzysztof Zembrzuski, Holly Steach, Kira Rubtsova, Davide Angeletti, Alexander Lemenze, Brian J. Laidlaw, Joe Craft, Jason S. Weinstein

Issue&Volume: 2022-01-27

Abstract: Tbet+CD11c+ B cells arise during type 1 pathogen challenge, aging, and autoimmunity in mice andhumans. Here, we examined the developmental requirements of this B cell subset. Inacute infection, T follicular helper (Tfh) cells, but not Th1 cells, drove Tbet+CD11c+ B cell generation through proximal delivery of help. Tbet+CD11c+ B cells developed prior to germinal center (GC) formation, exhibiting phenotypicand transcriptional profiles distinct from GC B cells. Fate tracking revealed thatmost Tbet+CD11c+ B cells developed independently of GC entry and cell-intrinsic Bcl6 expression. Tbet+CD11c+ and GC B cells exhibited minimal repertoire overlap, indicating distinct developmentalpathways. As the infection resolved, Tbet+CD11c+ B cells localized to the marginal zone where splenic retention depended on integrinsLFA-1 and VLA-4, forming a competitive memory subset that contributed to antibodyproduction and secondary GC seeding upon rechallenge. Therefore, Tbet+CD11c+ B cells comprise a GC-independent memory subset capable of rapid and robust recallresponses.

DOI: 10.1016/j.immuni.2022.01.002

Source: https://www.cell.com/immunity/fulltext/S1074-7613(22)00031-0

Immunity：《免疫》，创刊于1994年。隶属于细胞出版社，最新IF：43.474
官方网址：https://www.cell.com/immunity/home
投稿链接：https://www.editorialmanager.com/immunity/default.aspx