小柯机器人

澳大利亚昆士兰大学Tara L. Walker等研究人员合作发现，硒介导运动诱导的成人神经发生并逆转海马损伤和衰老引起的学习障碍。相关论文于2022年2月3日在线发表在《细胞—代谢》杂志上。

据研究人员介绍，尽管对运动的神经发生增强作用进行了广泛的研究，但这种反应的分子机制仍不清楚。

Title: Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging

Author: Odette Leiter, Zhan Zhuo, Ruslan Rust, Joanna M. Wasielewska, Lisa Grnnert, Susann Kowal, Rupert W. Overall, Vijay S. Adusumilli, Daniel G. Blackmore, Adam Southon, Katherine Ganio, Christopher A. McDevitt, Nicole Rund, David Brici, Imesh Aththanayake Mudiyan, Alexander M. Sykes, Annette E. Rünker, Sara Zocher, Scott Ayton, Ashley I. Bush, Perry F. Bartlett, Sheng-Tao Hou, Gerd Kempermann, Tara L. Walker

Issue&Volume: 2022-02-03

Abstract: Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory.

DOI: 10.1016/j.cmet.2022.01.005

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00005-5

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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