小柯机器人

法国PSL大学居里研究所研究中心Julie Helft研究团队近期取得重要工作进展，他们研究发现组织驻留的FOLR2+巨噬细胞与人乳腺癌中CD8+ T细胞的浸润有关，这一研究成果2022年3月23日在线发表于《细胞》杂志上。

在这里，研究人员在健康乳腺和乳腺癌原发性肿瘤中发现了一个离散的FOLR2+组织常驻巨噬细胞群体。FOLR2+巨噬细胞定位于肿瘤间质的血管周围区域，在那里它们与CD8+ T细胞相互作用。FOLR2+巨噬细胞在体外有效地引发效应CD8+ T细胞。肿瘤中FOLR2+巨噬细胞的密度与患者的生存率呈正相关。该研究突出了肿瘤相关巨噬细胞亚群的特定作用，并为基于巨噬细胞的癌症治疗中的亚群靶向治疗干预铺平了道路。

据介绍，巨噬细胞浸润是实体癌的标志，整体巨噬细胞浸润与较低的患者存活率和对治疗的抵抗力相关。 然而，肿瘤相关巨噬细胞在表型和功能上是异质的。 肿瘤相关巨噬细胞的特定亚群可能在癌症进展和抗肿瘤免疫中具有不同的作用。

附：英文原文

Title: Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Author: Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Yohan Gerber-Ferder, Christian P. Bromley, Mattia Bugatti, Nicolas Gonzalo Núez, Jimena Tosello Boari, Wilfrid Richer, Laurie Menger, Jordan Denizeau, Christine Sedlik, Pamela Caudana, Fiorella Kotsias, Leticia L. Niborski, Sophie Viel, Mylène Bohec, Sonia Lameiras, Sylvain Baulande, Latitia Lesage, André Nicolas, Didier Meseure, Anne Vincent-Salomon, Fabien Reyal, Charles-Antoine Dutertre, Florent Ginhoux, Lene Vimeux, Emmanuel Donnadieu, Bénédicte Buttard, Jérme Galon, Santiago Zelenay, William Vermi, Pierre Guermonprez, Eliane Piaggio, Julie Helft

Issue&Volume: 2022-03-23

Abstract: Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltrationcorrelates with lower patient survival and resistance to therapy. Tumor-associatedmacrophages, however, are phenotypically and functionally heterogeneous. Specificsubsets of tumor-associated macrophage might be endowed with distinct roles on cancerprogression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interactwith CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This studyhighlights specific roles for tumor-associated macrophage subsets and paves the wayfor subset-targeted therapeutic interventions in macrophages-based cancer therapies.

DOI: 10.1016/j.cell.2022.02.021

Source: https://www.cell.com/cell/fulltext/S0092-8674(22)00201-X