小柯机器人

中南大学罗湘杭团队发现，骨髓中的机械敏感性脂肪性因子促进成骨生成和淋巴生成。该项研究成果于2022年6月14日在线发表在《细胞—代谢》杂志上。

Author: Hui Peng, Biao Hu, Ling-Qi Xie, Tian Su, Chang-Jun Li, Ya Liu, Mi Yang, Ye Xiao, Xu Feng, Rui Zhou, Qi Guo, Hai-Yan Zhou, Yan Huang, Tie-Jian Jiang, Xiang-Hang Luo

Issue&Volume: 2022-06-14

Abstract: Exercise can prevent osteoporosis and improve immune function, but the mechanism remainsunclear. Here, we show that exercise promotes reticulocalbin-2 secretion from thebone marrow macrophages to initiate bone marrow fat lipolysis. Given the crucial roleof lipolysis in exercise-stimulated osteogenesis and lymphopoiesis, these findingssuggest that reticulocalbin-2 is a pivotal regulator of a local adipose-osteogenic/immuneaxis. Mechanistically, reticulocalbin-2 binds to a functional receptor complex, whichis composed of neuronilin-2 and integrin beta-1, to activate a cAMP-PKA signalingpathway that mobilizes bone marrow fat via lipolysis to fuel the differentiation andfunction of mesenchymal and hematopoietic stem cells. Notably, the administrationof recombinant reticulocalbin-2 in tail-suspended and old mice remarkably decreasesbone marrow fat accumulation and promotes osteogenesis and lymphopoiesis. These findingsidentify reticulocalbin-2 as a novel mechanosensitive lipolytic factor in maintainingenergy homeostasis in bone resident cells, and it provides a promising target forskeletal and immune health.

DOI: 10.1016/j.cmet.2022.05.009

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00191-7

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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