中国科学院过程工程研究所王丹团队开发了具有开关和速率调节功能的PEG功能化中空多层结构用于可控抗菌药物释放。相关研究成果于2022年6月22日发表于国际顶尖学术期刊《德国应用化学》。
构建具有多功能和可控释放的响应性抗菌载体是一个有吸引力但具有挑战性的命题。最近发展起来的空心多层结构（HoMSs）具有固有的结构优势，例如易于修改的表面和相互影响的壳体。因此，为实现其在药物输送系统中的潜力，人们付出了巨大的努力。
该文中，研究人员报道了一种新型的pH响应性抗菌载体，其具有多层次的外壳作为多级响应体，使用聚乙二醇（PEG）作为门控调节器。PEG功能化壳之间的相互作用赋予它们pH响应开关和速率调节能力。这些特征表现为包裹在外壳中的分子快速释放，以及通过静电相互作用控制储存在外壳中的抗菌剂的扩散，从而产生长达71天的持久防霉性。HOMs层次化相互作用的多功能性将启发有希望的智能药物载体的设计。
附：英文原文
Title: PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release
Author: Decai Zhao, Yanze Wei, Quan Jin, Nailiang Yang, Yang Yang, Dan Wang
Issue&Volume: 2022-06-22
Abstract: The construction of responsive antimicrobial carriers with multifunctional and controllable release is an attractive but challenging proposition. Recently developed hollow multishelled structures (HoMSs) possess intrinsic structural advantages such as easily modifiable surfaces and mutually influenced shells. Therefore, significant efforts have been devoted to realize their potential in drug-delivery systems. Herein, we report a novel pH-responsive antimicrobial carrier having hierarchical shells as multilevel responsive bodies using polyethylene glycol (PEG) as a gated regulator. The interaction between PEG-functionalized shells endows them with a pH-responsive switch and rate-regulator capability. These features are present in the form of rapid release of molecules wrapped in the outer shell, and controlled diffusion of antimicrobials stored in the inner shell by electrostatic interaction, respectively, resulting in a long-lasting mildew resistance for up to 71 days. The versatility of the hierarchical interactions of HoMSs will inspire the design of promising smart drug carriers.
DOI: 10.1002/anie.202206807
Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202206807
