小柯机器人

眶额叶皮层去抑制会影响肥胖走向，这一成果由加拿大卡尔加里大学Stephanie L. Borgland研究团队经过不懈努力而取得。该研究成果于2022年12月15日发表在国际学术期刊《自然-神经科学》上。

研究人员发现了外侧眶额叶皮层（lOFC）在肥胖行为认知控制中的新功能。肥胖患者有倾向性的食物寻找行为，因此在雄性肥胖小鼠中，行为对结果价值变化的感知不太灵敏。在lOFC诱导的肥胖样损伤小鼠中，肥胖与lOFC抑制减弱和GABA化学遗传学减少有关。相反，用药物抑制或光遗传学恢复肥胖小鼠的lOFC神经传递恢复了其灵活的行为。该研究结果表明，肥胖诱导的lOFC去抑制导致无法用饱腹感获取食物价值变化，这反过来可能会影响个体在致胖环境中的决策方式。

研究人员表示，lOFC接收与食物有关的信号，并将这些信号与预期结果相结合，以指导未来的行动，其可能在调节进食行为的神经回路网络中发挥关键作用。

附：英文原文

Title: Disinhibition of the orbitofrontal cortex biases decision-making in obesity

Author: Seabrook, Lauren T., Naef, Lindsay, Baimel, Corey, Judge, Allap K., Kenney, Tyra, Ellis, Madelyn, Tayyab, Temoor, Armstrong, Mataea, Qiao, Min, Floresco, Stan B., Borgland, Stephanie L.

Issue&Volume: 2022-12-15

Abstract: The lateral orbitofrontal cortex (lOFC) receives sensory information about food and integrates these signals with expected outcomes to guide future actions, and thus may play a key role in a distributed network of neural circuits that regulate feeding behavior. Here, we reveal a new role for the lOFC in the cognitive control of behavior in obesity. Food-seeking behavior is biased in obesity such that in male obese mice, behaviors are less flexible to changes in the perceived value of the outcome. Obesity is associated with reduced lOFC inhibitory drive and chemogenetic reduction in GABAergic neurotransmission in the lOFC induces obesity-like impairments in goal-directed behavior. Conversely, pharmacological or optogenetic restoration of inhibitory neurotransmission in the lOFC of obese mice reinstates flexible behavior. Our results indicate that obesity-induced disinhibition of the lOFC leads to a failure to update changes in the value of food with satiety, which in turn may influence how individuals make decisions in an obesogenic environment.

DOI: 10.1038/s41593-022-01210-6

Source: https://www.nature.com/articles/s41593-022-01210-6

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex