小柯机器人

美国加州大学圣地亚哥分校John T. Chang团队近期取得重要工作进展，他们研究发现小肠和结肠组织驻留记忆CD8⁺ T细胞表现出分子异质性和对Eomes的差异依赖性。该项研究成果2022年12月28日在线发表于《免疫》杂志上。

据介绍，组织驻留记忆CD8⁺ T（T_RM）细胞是记忆T细胞的一个子集，在限制早期病原体传播和控制感染方面发挥关键作用。T_RM细胞在不同组织中表现出差异，但它们在小肠和结肠内不同解剖区室中的潜在异质性尚未得到充分认识。

通过分析小肠和结肠固有层和上皮区室的T_RM细胞，研究人员发现肠道T_RM细胞表现出独特的细胞因子和颗粒酶表达模式，以及显著的转录、表观遗传和功能异质性。T-box转录因子Eomes在某些组织中抑制T_RM细胞的形成，在支持小肠（但不是结肠）中已建立的T_RM细胞维持方面表现出环境特异性的调节作用。

总之，这些数据为肠道T_RM细胞形成与维持的异质性和差异性需求提供了以前未被认可的见解。

附：英文原文

Title: Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

Author: Yun Hsuan Lin, Han G. Duong, Abigail E. Limary, Eleanor S. Kim, Paul Hsu, Shefali A. Patel, William H. Wong, Cynthia S. Indralingam, Yi Chia Liu, Priscilla Yao, Natalie R. Chiang, Sara A. Vandenburgh, Taylor R. Anderson, Jocelyn G. Olvera, Amir Ferry, Kennidy K. Takehara, Wenhao Jin, Matthew S. Tsai, Gene W. Yeo, Ananda W. Goldrath, John T. Chang

Issue&Volume: 2022-12-28

Abstract: Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that play a critical role in limiting earlypathogen spread and controlling infection. TRM cells exhibit differences across tissues, but their potential heterogeneity amongdistinct anatomic compartments within the small intestine and colon has not been wellrecognized. Here, by analyzing TRM cells from the lamina propria and epithelial compartments of the small intestineand colon, we showed that intestinal TRM cells exhibited distinctive patterns of cytokine and granzyme expression along withsubstantial transcriptional, epigenetic, and functional heterogeneity. The T-box transcriptionfactor Eomes, which represses TRM cell formation in some tissues, exhibited unexpected context-specific regulatoryroles in supporting the maintenance of established TRM cells in the small intestine, but not in the colon. Taken together, these data providepreviously unappreciated insights into the heterogeneity and differential requirementsfor the formation vs. maintenance of intestinal TRM cells.

DOI: 10.1016/j.immuni.2022.12.007

Source: https://www.cell.com/immunity/fulltext/S1074-7613(22)00643-4

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