小柯机器人

美国霍华德休斯医学研究所Jan Funke小组开发出用于神经元分割的局部形状描述符。相关论文于2022年12月30日在线发表在《自然—方法学》杂志上。

Title: Local shape descriptors for neuron segmentation

Author: Sheridan, Arlo, Nguyen, Tri M., Deb, Diptodip, Lee, Wei-Chung Allen, Saalfeld, Stephan, Turaga, Srinivas C., Manor, Uri, Funke, Jan

Issue&Volume: 2022-12-30

Abstract: We present an auxiliary learning task for the problem of neuron segmentation in electron microscopy volumes. The auxiliary task consists of the prediction of local shape descriptors (LSDs), which we combine with conventional voxel-wise direct neighbor affinities for neuron boundary detection. The shape descriptors capture local statistics about the neuron to be segmented, such as diameter, elongation, and direction. On a study comparing several existing methods across various specimen, imaging techniques, and resolutions, auxiliary learning of LSDs consistently increases segmentation accuracy of affinity-based methods over a range of metrics. Furthermore, the addition of LSDs promotes affinity-based segmentation methods to be on par with the current state of the art for neuron segmentation (flood-filling networks), while being two orders of magnitudes more efficient—a critical requirement for the processing of future petabyte-sized datasets.

DOI: 10.1038/s41592-022-01711-z

Source: https://www.nature.com/articles/s41592-022-01711-z

Nature Methods：《自然—方法学》，创刊于2004年。隶属于施普林格·自然出版集团，最新IF：47.99
官方网址：https://www.nature.com/nmeth/
投稿链接：https://mts-nmeth.nature.com/cgi-bin/main.plex