小柯机器人

德国维尔茨堡大学医院Philip Tovote团队近期取得重要工作进展，他们通过对威胁的综合有氧行为反应定义了防御状态。相关研究成果2023年2月9日在线发表于《自然—神经科学》杂志上。

据介绍，恐惧和焦虑是大脑中的一种状态，进化为调节对威胁的防御反应。防御反应包括多种相互作用的行为调节、自主调节和内分泌调节，但它们的综合性尚不清楚。特别是，尽管威胁与各种心脏变化有关，但对于这些变化与综合防御反应的相关性尚无明确共识。

研究人员确定了与特定行为和心率动态相关的快速微观状态，这些状态受到长期宏观状态的影响，并反映了与环境相关的威胁水平。此外，研究人员还证明，最常用的防御行为反应之一（通过静止来测量）是由导水管周围灰质中Chx10⁺神经元介导的综合有氧行为微观状态的一部分。

总之，这一心脏和行为读数系统集成框架为更好地理解复杂的神经防御状态及其相关的系统功能提供了基础。

附：英文原文

Title: Integrated cardio-behavioral responses to threat define defensive states

Author: Signoret-Genest, Jrmy, Schukraft, Nina, L. Reis, Sara, Segebarth, Dennis, Deisseroth, Karl, Tovote, Philip

Issue&Volume: 2023-02-09

Abstract: Fear and anxiety are brain states that evolved to mediate defensive responses to threats. The defense reaction includes multiple interacting behavioral, autonomic and endocrine adjustments, but their integrative nature is poorly understood. In particular, although threat has been associated with various cardiac changes, there is no clear consensus regarding the relevance of these changes for the integrated defense reaction. Here we identify rapid microstates that are associated with specific behaviors and heart rate dynamics, which are affected by long-lasting macrostates and reflect context-dependent threat levels. In addition, we demonstrate that one of the most commonly used defensive behavioral responses—freezing as measured by immobility—is part of an integrated cardio-behavioral microstate mediated by Chx10+ neurons in the periaqueductal gray. Our framework for systematic integration of cardiac and behavioral readouts presents the basis for a better understanding of complex neural defensive states and their associated systemic functions.

DOI: 10.1038/s41593-022-01252-w

Source: https://www.nature.com/articles/s41593-022-01252-w

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex