小柯机器人

近日，武汉大学李艳等研究人员合作发现，肠道微生物表达的3β-羟类固醇脱氢酶可降解雌二醇，并与绝经前女性的抑郁症有关。相关论文于2023年3月17日发表于国际顶尖学术期刊《细胞—代谢》杂志上。

研究人员从患有抑郁症的绝经前女性的粪便中分离出了降解雌二醇的产气克雷伯菌（Klebsiella aerogenes）。在小鼠中，灌喂该菌株导致雌二醇下降和抑郁症样行为。编码产气克雷伯菌中雌二醇降解酶的基因被确定为3β-羟类固醇脱氢酶（3β-HSD）。异源表达3β-HSD导致大肠杆菌获得降解雌二醇的能力。用表达3β-HSD的大肠杆菌灌喂小鼠，使其血清雌二醇水平下降，引起类似抑郁症的行为。在患有抑郁症的绝经前妇女中，产气克雷伯菌和3β-HSD的流行率比没有抑郁症的妇女高。

这些结果表明，雌二醇降解细菌和3β-HSD酶是绝经前妇女抑郁症治疗的潜在干预目标。

据悉，雌二醇下降可导致女性的抑郁症；然而，这种下降的原因尚不清楚。

附：英文原文

Title: Gut-microbiome-expressed 3β-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females

Author: Di Li, Ting Sun, Yongqing Tong, Juan Le, Qian Yao, Jun Tao, Hang Liu, Woer Jiao, Yufeng Mei, Jingru Chen, Zhongchun Liu, Gaohua Wang, Yan Li

Issue&Volume: 2023-03-17

Abstract: Estradiol decline can result in depressive disorders in females; nevertheless, the causes of this decline are unclear. In this study, we isolated estradiol-degrading Klebsiella aerogenes from the feces of premenopausal females with depression. In mice, gavaging with this strain led to estradiol decline and depression-like behaviors. The gene encoding the estradiol-degrading enzyme in K. aerogenes was identified as 3β-hydroxysteroid dehydrogenase (3β-HSD). Heterologously expressing 3β-HSD resulted in Escherichia coli obtaining the ability to degrade estradiol. Gavaging mice with 3β-HSD-expressing E. coli decreased their serum estradiol levels, causing depression-like behaviors. The prevalence of K. aerogene and 3β-HSD was higher in premenopausal women with depression than in those without depression. These results suggest that the estradiol-degrading bacteria and 3β-HSD enzymes are potential intervention targets for depression treatment in premenopausal women.

DOI: 10.1016/j.cmet.2023.02.017

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00053-0

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