香港中文大学唐本忠团队通过精确双受体工程同步操纵半导体聚合物的吸收和消光系数用于NIR-II激发光热治疗。相关研究成果于2023年3月17日发表在国际顶尖学术期刊《德国应用化学》。
将所有超长激发波长、高消光系数和突出的光热转换能力集成到单个光热试剂中，是一项有吸引力但极具挑战性的任务。
该文中，基于供体-受体（D–a）型半导体聚合物，研究人员通过巧妙地调节具有不同电子亲和力和π-共轭度的两个电子受体部分的摩尔比，并充分利用分子内运动诱导的光热效应，开发了一种精确的双受体工程策略。最佳聚合物SP4同时显示出理想的第二近红外（NIR-II）吸收、极高的消光系数和令人满意的光热转换行为。通过精确的肿瘤诊断和完全的肿瘤消除结果证明了，SP4-NPs在1064nm激光激发光声成像（PAI）引导的光热治疗（PTT）上的前所未有的性能。
附：英文原文
Title: Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual-Acceptor Engineering for NIR-II Excited Photothermal Theranostics
Author: Jiangao Li, Miaomiao Kang, Zhijun Zhang, Xue Li, Weilin Xu, Dong Wang, Xike Gao, Ben Zhong Tang
Issue&Volume: 2023-03-17
Abstract: Integrating all of the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual-acceptor engineering strategy is exploited for this attempt based on donor-acceptor (D–A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featured with different electronic affinity and π-conjugation degrees, and taking full use of the active intramolecular motion-induced photothermal effect. The optimal polymer SP4, synchronously shows desirable second near-infrared (NIR-II) absorption, extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser-excited photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes.
DOI: 10.1002/anie.202301617
Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202301617
