小柯机器人

美国哈佛医学院Dragana Rogulja发现，一种肠道分泌的肽抑制从睡眠中唤醒的能力。2023年3月22日，《细胞》杂志在线发表了这项成果。

研究人员表明，当食物富含蛋白质时，睡眠中的果蝇和小鼠对机械振动的反应性得到更好的抑制。在果蝇中，研究人员描述了一个信号通路，通过该通路，有关摄入蛋白质的信息从肠道传达给大脑，进而帮助抑制唤醒能力。肠道中较高的蛋白质浓度导致释放多肽CCHa1的肠道内分泌细胞的活动增加。CCHa1向大脑中的一小群多巴胺神经元发出信号，以调节其活动；多巴胺能活动调节动物对振动的行为反应性。CCHa1途径和饮食蛋白并不影响对所有感觉输入的反应性，这表明在睡眠期间，不同的信息流可以通过独立的机制进行门控。

据介绍，抑制感官唤醒对睡眠至关重要，更深的睡眠需要更强的感官抑制。使睡眠中的动物能够在很大程度上忽略其周围环境的机制还不是很清楚。

附：英文原文

Title: A gut-secreted peptide suppresses arousability from sleep

Author: Iris Titos, Alen Juginovi, Alexandra Vaccaro, Keishi Nambara, Pavel Gorelik, Ofer Mazor, Dragana Rogulja

Issue&Volume: 2023-03-22

Abstract: Suppressing sensory arousal is critical for sleep, with deeper sleep requiring stronger sensory suppression. The mechanisms that enable sleeping animals to largely ignore their surroundings are not well understood. We show that the responsiveness of sleeping flies and mice to mechanical vibrations is better suppressed when the diet is protein rich. In flies, we describe a signaling pathway through which information about ingested proteins is conveyed from the gut to the brain to help suppress arousability. Higher protein concentration in the gut leads to increased activity of enteroendocrine cells that release the peptide CCHa1. CCHa1 signals to a small group of dopamine neurons in the brain to modulate their activity; the dopaminergic activity regulates the behavioral responsiveness of animals to vibrations. The CCHa1 pathway and dietary proteins do not influence responsiveness to all sensory inputs, showing that during sleep, different information streams can be gated through independent mechanisms.

DOI: 10.1016/j.cell.2023.02.022

Source: https://www.cell.com/cell/fulltext/S0092-8674(23)00165-4