近日，美国哈佛医学院Vadim N. Gladyshev等研究人员发现，生物年龄因压力而增加并在恢复后复原。相关论文于2023年4月21日在线发表于国际学术期刊《细胞—代谢》。
研究人员报告说，生物年龄是不稳定的，并在两个方向上表现出快速变化。在表观遗传学、转录组和代谢组水平上，研究人员发现年轻小鼠的生物年龄因异时异种共生而增加，并在手术分离后恢复。研究人员还发现在人类和/或小鼠的大手术、怀孕和严重的COVID-19期间，生物年龄会发生短暂的变化。这些数据共同表明，生物年龄在应对不同形式的压力时经历了快速增长，在从压力中恢复后又被逆转。这项研究发现了一个新的衰老动态层，应该在未来的研究中予以考虑。压力导致的生物年龄的增加可能是未来干预措施的一个可量化和可操作的靶点。
据了解，经典的概念是，衰老是一个不断增加的损伤积累和功能丧失的轨迹，导致发病率和死亡率的增加。然而，最近的体外研究提出了年龄逆转的可能性。
附：英文原文
Title: Biological age is increased by stress and restored upon recovery
Author: Jesse R. Poganik, Bohan Zhang, Gurpreet S. Baht, Alexander Tyshkovskiy, Amy Deik, Csaba Kerepesi, Sun Hee Yim, Ake T. Lu, Amin Haghani, Tong Gong, Anna M. Hedman, Ellika Andolf, Gran Pershagen, Catarina Almqvist, Clary B. Clish, Steve Horvath, James P. White, Vadim N. Gladyshev
Issue&Volume: 2023-04-21
Abstract: Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.
DOI: 10.1016/j.cmet.2023.03.015
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00093-1
Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
官方网址：https://www.cell.com/cell-metabolism/home
投稿链接：https://www.editorialmanager.com/cell-metabolism/default.aspx
本期文章：《细胞—代谢》：Online/在线发表
