小柯机器人

美国加州大学Itzhak Fried和以色列特拉维夫大学Yuval Nir共同合作，近期取得重要工作进展。他们研究发现在睡眠期间增强海马-前额叶神经元同步可增强人类的记忆巩固。相关研究成果2023年6月1日在线发表于《自然—神经科学》杂志上。

据介绍，睡眠中的记忆巩固被认为取决于皮层慢波、丘脑皮层睡眠纺锤体和海马涟漪之间的协调相互作用，但缺乏直接证据。

研究人员在睡眠期间对人类前额叶皮层进行了实时闭环脑深部刺激，并测试了其对睡眠电生理学和夜间巩固陈述性记忆的影响。将刺激与内侧颞叶（MTL）内源性慢波的活动相同步可增强了睡眠纺锤波，促进全脑神经尖峰活动对MTL慢波的锁定，并改善MTL波纹和丘脑皮质振荡之间的耦合。

此外，同步刺激提高了识别记忆的准确性。相比之下，没有这种精确时间锁定的相同刺激与这些电生理和行为效应无关，有时甚至会退化。值得注意的是，记忆准确性的个体变化与电生理效应高度相关。

总之，这一研究表明，睡眠中的海马-丘脑皮质同步是支持人类记忆巩固的原因。

附：英文原文

Title: Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans

Author: Geva-Sagiv, Maya, Mankin, Emily A., Eliashiv, Dawn, Epstein, Shdema, Cherry, Natalie, Kalender, Guldamla, Tchemodanov, Natalia, Nir, Yuval, Fried, Itzhak

Issue&Volume: 2023-06-01

Abstract: Memory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but direct evidence is lacking. Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex during sleep and tested its effects on sleep electrophysiology and on overnight consolidation of declarative memory. Synchronizing the stimulation to the active phases of endogenous slow waves in the medial temporal lobe (MTL) enhanced sleep spindles, boosted locking of brain-wide neural spiking activity to MTL slow waves, and improved coupling between MTL ripples and thalamocortical oscillations. Furthermore, synchronized stimulation enhanced the accuracy of recognition memory. By contrast, identical stimulation without this precise time-locking was not associated with, and sometimes even degraded, these electrophysiological and behavioral effects. Notably, individual changes in memory accuracy were highly correlated with electrophysiological effects. Our results indicate that hippocampo–thalamocortical synchronization during sleep causally supports human memory consolidation.

DOI: 10.1038/s41593-023-01324-5

Source: https://www.nature.com/articles/s41593-023-01324-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex