小柯机器人

丹麦哥本哈根大学Maiken Nedergaard团队近期取得重要工作进展，他们研究发现神经-血管耦合能加速类淋巴系统的内流和清除。相关研究成果2023年6月1日在线发表于《自然—神经科学》杂志上。

据介绍，功能性充血，也称为神经-血管耦合，是当神经活动增加局部脑血流量时发生的一种现象。

由于所有的生物活性都会产生代谢废物，研究人员试图通过免疫系统研究功能性充血和废物清除之间的关系。分析表明，胡须刺激增加了小鼠体感皮层的神经节内流和清除率，激活半球的动脉周围脑脊液（CSF）内流速度增加了1.6倍。粒子跟踪测速技术揭示了动脉扩张/收缩与动脉周围脑脊液流速之间的直接耦合。血管平滑肌细胞的光遗传学操作在缺乏神经激活的情况下增强了类淋巴系统的内流。研究人员提出，阻抗泵送允许动脉搏动沿着与血流相同的方向驱动CSF，并提出了一个支持这一想法的模拟。

因此，这一研究表明，功能性充血不仅能促进代谢产物的供应，还能清除代谢废物。

附：英文原文

Title: Glymphatic influx and clearance are accelerated by neurovascular coupling

Author: Holstein-Rnsbo, Stephanie, Gan, Yiming, Giannetto, Michael J., Rasmussen, Martin Kaag, Sigurdsson, Bjrn, Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, Lauren M., Kelley, Douglas H., Nedergaard, Maiken

Issue&Volume: 2023-06-01

Abstract: Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs when neural activity increases local cerebral blood flow. Because all biological activity produces metabolic waste, we here sought to investigate the relationship between functional hyperemia and waste clearance via the glymphatic system. The analysis showed that whisker stimulation increased both glymphatic influx and clearance in the mouse somatosensory cortex with a 1.6-fold increase in periarterial cerebrospinal fluid (CSF) influx velocity in the activated hemisphere. Particle tracking velocimetry revealed a direct coupling between arterial dilation/constriction and periarterial CSF flow velocity. Optogenetic manipulation of vascular smooth muscle cells enhanced glymphatic influx in the absence of neural activation. We propose that impedance pumping allows arterial pulsatility to drive CSF in the same direction as blood flow, and we present a simulation that supports this idea. Thus, functional hyperemia boosts not only the supply of metabolites but also the removal of metabolic waste.

DOI: 10.1038/s41593-023-01327-2

Source: https://www.nature.com/articles/s41593-023-01327-2

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex