小柯机器人

美国哥伦比亚大学欧文医学中心Donna L. Farber团队近期取得重要工作进展，他们研究发现婴儿期和儿童期人类组织驻留记忆T细胞的位点特异性发育和逐渐成熟。相关研究成果2023年7月7日在线发表于《免疫》杂志上。

据介绍，婴儿期和儿童期是产生免疫记忆以抵御病原体的关键生命阶段，然而，人类记忆发展的时间、地点和途径仍然难以捉摸。

研究人员使用表型、功能和转录组分析研究了96名0–10岁儿童捐赠者的粘膜部位、淋巴组织和血液中的T细胞。研究结果表明，与血液和淋巴器官相比，记忆T细胞在婴儿期优先定位在肠和肺中，并在粘膜部位更快地积累，这与位点特异性抗原暴露一致。早期粘膜记忆T细胞表现出不同的功能和干细胞样转录谱。在儿童后期，它们逐渐采用促炎功能和组织驻留特征，与粘膜和淋巴部位T细胞受体（TCR）克隆扩增增加一致。

总之，这一发现确定了在形成期靶向组织的记忆T细胞的阶段性发育，为人们如何促进和监测儿童的免疫力提供了信息。

附：英文原文

Title: Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood

Author: Thomas J. Connors, Rei Matsumoto, Shivali Verma, Peter A. Szabo, Rebecca Guyer, Joshua Gray, Zicheng Wang, Puspa Thapa, Pranay Dogra, Maya M.L. Poon, Ksenia Rybkina, Marissa C. Bradley, Emma Idzikowski, James McNichols, Masaru Kubota, Kalpana Pethe, Yufeng Shen, Mark A. Atkinson, Maigan Brusko, Todd M. Brusko, Andrew J. Yates, Peter A. Sims, Donna L. Farber

Issue&Volume: 2023-07-07

Abstract: Infancy and childhood are critical life stages for generating immune memory to protectagainst pathogens; however, the timing, location, and pathways for memory developmentin humans remain elusive. Here, we investigated T cells in mucosal sites, lymphoidtissues, and blood from 96 pediatric donors aged 0–10 years using phenotypic, functional,and transcriptomic profiling. Our results revealed that memory T cells preferentiallylocalized in the intestines and lungs during infancy and accumulated more rapidlyin mucosal sites compared with blood and lymphoid organs, consistent with site-specificantigen exposure. Early life mucosal memory T cells exhibit distinct functional capacitiesand stem-like transcriptional profiles. In later childhood, they progressively adoptproinflammatory functions and tissue-resident signatures, coincident with increasedT cell receptor (TCR) clonal expansion in mucosal and lymphoid sites. Together, ourfindings identify staged development of memory T cells targeted to tissues duringthe formative years, informing how we might promote and monitor immunity in children.

DOI: 10.1016/j.immuni.2023.06.008

Source: https://www.cell.com/immunity/fulltext/S1074-7613(23)00265-0

Immunity：《免疫》，创刊于1994年。隶属于细胞出版社，最新IF：43.474
官方网址：https://www.cell.com/immunity/home
投稿链接：https://www.editorialmanager.com/immunity/default.aspx