小柯机器人

葡萄牙尚帕利莫基金会Joseph J. Paton研究组的研究利用温度控制分析了时间决策的神经基础。2023年7月13日出版的《自然—神经科学》发表了这项成果。

研究人员检测了温度对纹状体细胞活动和大鼠行为的影响，并将观察到的影响与在多个不同时间分类任务中收集的神经活动和行为进行了比较。冷却导致扩张而变暖产生收缩，这两种神经活动和时间上的神经判断模式模仿了纹状体活动中与内源性决策相关的变异性。

然而，温度并没有类似地影响运动动力学。这些数据提供了令人信服的证据，表明纹状体活动演变的时间过程决定了选择潜在过程的速度，而不是连续的运动控制。更广泛地说，他们认为种群活动的时间尺度是时间行为可能的神经基础。

研究人员表示，一些研究认为基底神经节有助于决策和运动控制。这些功能高度依赖于时间信息，这些信息可以从神经细胞的主要输入结构纹状体的进化中获得。然而，对纹状体活动是潜在的动态决策过程还是动态运动学过程存在争议。

附：英文原文

Title: Using temperature to analyze the neural basis of a time-based decision

Author: Monteiro, Tiago, Rodrigues, Filipe S., Pexirra, Margarida, Cruz, Bruno F., Gonalves, Ana I., Rueda-Orozco, Pavel E., Paton, Joseph J.

Issue&Volume: 2023-07-13

Abstract: The basal ganglia are thought to contribute to decision-making and motor control. These functions are critically dependent on timing information, which can be extracted from the evolving state of neural populations in their main input structure, the striatum. However, it is debated whether striatal activity underlies latent, dynamic decision processes or kinematics of overt movement. Here, we measured the impact of temperature on striatal population activity and the behavior of rats, and compared the observed effects with neural activity and behavior collected in multiple versions of a temporal categorization task. Cooling caused dilation, and warming contraction, of both neural activity and patterns of judgment in time, mimicking endogenous decision-related variability in striatal activity. However, temperature did not similarly affect movement kinematics. These data provide compelling evidence that the timecourse of evolving striatal activity dictates the speed of a latent process that is used to guide choices, but not continuous motor control. More broadly, they establish temporal scaling of population activity as a likely neural basis for variability in timing behavior.

DOI: 10.1038/s41593-023-01378-5

Source: https://www.nature.com/articles/s41593-023-01378-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex