小柯机器人

美国西北大学Daniel A. Dombeck和Rajeshwar Awatramani共同合作，近期取得重要工作进展。他们研究发现，独特的功能反应差异映射到多巴胺神经元的遗传亚型。相关研究成果2023年8月3日在线发表于《自然—神经科学》杂志上。

据介绍，多巴胺神经元的特征是它们对意外奖励的反应，但它们也会在运动和厌恶刺激时放电。多巴胺神经元的多样性已经根据分子表达谱进行了观察，然而，不同的功能是否映射到这些基因亚型上仍不清楚。

研究人员确定了黑质致密部内的三种遗传多巴胺亚型，以Slc17a6（Vglut2）、Calb1和Anxa1的表达为特征，每种亚型对奖励、厌恶性刺激以及加速和减速都有一组独特的反应，这些信号模式在亚型内的体细胞和轴突之间高度相关。值得注意的是，Anxa1⁺亚型几乎完全没有奖励反应，而是显示出与加速度相关的信号。

总之，这一发现建立了功能性和遗传性多巴胺亚型之间的联系，并证明分子表达模式可以作为剖析多巴胺能功能的共同框架。

附：英文原文

Title: Unique functional responses differentially map onto genetic subtypes of dopamine neurons

Author: Azcorra, Maite, Gaertner, Zachary, Davidson, Connor, He, Qianzi, Kim, Hailey, Nagappan, Shivathmihai, Hayes, Cooper K., Ramakrishnan, Charu, Fenno, Lief, Kim, Yoon Seok, Deisseroth, Karl, Longnecker, Richard, Awatramani, Rajeshwar, Dombeck, Daniel A.

Issue&Volume: 2023-08-03

Abstract: Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1 and Anxa1, each have a unique set of responses to rewards, aversive stimuli and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes. Remarkably, reward responses were almost entirely absent in the Anxa1+ subtype, which instead displayed acceleration-correlated signaling. Our findings establish a connection between functional and genetic dopamine subtypes and demonstrate that molecular expression patterns can serve as a common framework to dissect dopaminergic functions.

DOI: 10.1038/s41593-023-01401-9

Source: https://www.nature.com/articles/s41593-023-01401-9

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex