小柯机器人

澳大利亚莫纳什大学Alex Fornito团队表征了精神疾病中脑异常的区域、回路和网络异质性。2023年8月14日出版的《自然—神经科学》杂志发表了这项成果。

他们对1294例诊断为6种疾病(注意缺陷/多动障碍、自闭症谱系障碍、双相情感障碍、抑郁症、强迫症和精神分裂症)的患者和1465例匹配对照患者的灰质体积(GMV)异质性进行了全面、多尺度的表征。规范模型表明，个体对区域GMV预期的偏差是高度异质性的，在同一诊断的人群中，影响同一区域的<7%。然而，在多达56%的病例中，这些偏差嵌入在共同的功能电路和网络中。

salience–ventral注意系统与其他系统选择性地涉及抑郁症、双相情感障碍、精神分裂症和注意缺陷/多动障碍。因此，相同诊断的病例之间的表型差异可能源于特定区域偏差的异质定位，而表型相似性可能归因于共同功能回路和网络的功能障碍。

研究人员表示，典型的病例对照研究往往忽略了精神疾病患者的个体异质性，这种研究依赖于群体均值比较。

附：英文原文

Title: Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Author: Segal, Ashlea, Parkes, Linden, Aquino, Kevin, Kia, Seyed Mostafa, Wolfers, Thomas, Franke, Barbara, Hoogman, Martine, Beckmann, Christian F., Westlye, Lars T., Andreassen, Ole A., Zalesky, Andrew, Harrison, Ben J., Davey, Christopher G., Soriano-Mas, Carles, Cardoner, Narcs, Tiego, Jeggan, Ycel, Murat, Braganza, Leah, Suo, Chao, Berk, Michael, Cotton, Sue, Bellgrove, Mark A., Marquand, Andre F., Fornito, Alex

Issue&Volume: 2023-08-14

Abstract: The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive–compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of people with the same diagnosis. However, these deviations were embedded within common functional circuits and networks in up to 56% of cases. The salience–ventral attention system was implicated transdiagnostically, with other systems selectively involved in depression, bipolar disorder, schizophrenia and attention-deficit/hyperactivity disorder. Phenotypic differences between cases assigned the same diagnosis may thus arise from the heterogeneous localization of specific regional deviations, whereas phenotypic similarities may be attributable to the dysfunction of common functional circuits and networks.

DOI: 10.1038/s41593-023-01404-6

Source: https://www.nature.com/articles/s41593-023-01404-6

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex