小柯机器人

美国宾夕法尼亚大学Casey H. Halpern研究团队发现人类海马中的一个促食欲亚网络。该研究于2023年8月30日在线发表于国际一流学术期刊《自然》。

研究人员将束流成像、颅内电生理学、皮层-皮层下诱发电位和脑清除三维组织学结合起来，确定了一个涉及外侧下丘脑并汇聚于海马亚区的促食欲回路。研究人员发现，低频功率受到甜脂食物线索的调节，而且这种调节在海马背外侧具有特异性。对表现出饮食行为失调的人类群体进行的这一回路的结构和功能分析显示，其连接性与体重指数成反比。总之，这种多模式方法描述了人类海马中与肥胖和相关进食障碍有关的促食欲亚网络。

据了解，直到最近人们才有了更具体的回路探测技术，为之前关于啮齿动物海马与食欲加工有关的报道提供了信息。据报道，这种功能至少有一部分是由下丘脑外侧输入介导的，包括那些涉及促食欲下丘脑外侧神经肽的神经肽，如黑色素浓缩激素。然而，这一回路在人类中仍然难以捉摸。

附：英文原文

Title: An orexigenic subnetwork within the human hippocampus

Author: Barbosa, Daniel A. N., Gattas, Sandra, Salgado, Juliana S., Kuijper, Fiene Marie, Wang, Allan R., Huang, Yuhao, Kakusa, Bina, Leuze, Christoph, Luczak, Artur, Rapp, Paul, Malenka, Robert C., Hermes, Dora, Miller, Kai J., Heifets, Boris D., Bohon, Cara, McNab, Jennifer A., Halpern, Casey H.

Issue&Volume: 2023-08-30

Abstract: Only recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing1,2,3,4. This function has been reported to be mediated at least in part by lateral hypothalamic inputs, including those involving orexigenic lateral hypothalamic neuropeptides, such as melanin-concentrating hormone5,6. This circuit, however, remains elusive in humans. Here we combine tractography, intracranial electrophysiology, cortico-subcortical evoked potentials, and brain-clearing 3D histology to identify an orexigenic circuit involving the lateral hypothalamus and converging in a hippocampal subregion. We found that low-frequency power is modulated by sweet-fat food cues, and this modulation was specific to the dorsolateral hippocampus. Structural and functional analyses of this circuit in a human cohort exhibiting dysregulated eating behaviour revealed connectivity that was inversely related to body mass index. Collectively, this multimodal approach describes an orexigenic subnetwork within the human hippocampus implicated in obesity and related eating disorders.

DOI: 10.1038/s41586-023-06459-w

Source: https://www.nature.com/articles/s41586-023-06459-w

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html