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美国纪念斯隆凯特琳癌症中心Joan Massagué团队近期取得重要工作进展，他们研究发现了TGF-β信号在健康和疾病中的重要作用。相关研究成果2023年9月14日在线发表于《细胞》杂志上。

据介绍，TGF-β调节系统在维持机体完整性方面发挥着至关重要的作用。

研究结果表明，TGF-β信号通过对共享生态系统中多种细胞类型的细胞增殖、表型可塑性、迁移、代谢适应和免疫监视的协调作用来控制后生动物胚胎发育、组织稳态和损伤修复。TGF-β信号传导缺陷，特别是在上皮细胞、组织成纤维细胞和免疫细胞中，会破坏免疫耐受，促进炎症，是纤维化和癌症发病机制的基础，会导致这些疾病对治疗产生抵抗力。

总之，这一研究结果阐明了TGF-β如何协调健康和疾病中的多细胞反应程序，以及如何利用这些知识来开发TGF-β系统疾病的治疗方法。

附：英文全文

Title: TGF-β signaling in health and disease

Author: Joan Massagué, Dean Sheppard

Issue&Volume: 2023/09/14

Abstract: The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and cancer, and contribute to the resistance of these diseases to treatment. Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.

DOI: 10.1016/j.cell.2023.07.036

Source: https://www.cell.com/cell/fulltext/S0092-8674(23)00851-6