小柯机器人

英国伦敦帝国理工学院William Wisden和Nicholas P. Franks课题组合作的最新研究表明前额叶皮层（PFC）中的生长抑素神经元通过视前和下丘脑外侧开启睡眠准备行为和睡眠。相关论文发表在2023年9月21日出版的《自然-神经科学》杂志上。

使用小鼠PFC中的活性标记，研究人员鉴定了对睡眠缺乏有反应的特别兴奋、快速尖峰、生长抑素表达和γ-氨基丁酸（GABA）（PFCS^st-GABA）细胞。这些细胞投射到外侧视前（LPO）下丘脑和外侧下丘脑（LH）。刺激LPO下丘脑中的PFCS^st-GABA末端引起睡眠准备行为（嵌套、θ功率升高和温度升高），刺激LH中的PFCS^st-GABA末端模拟睡眠恢复（具有较高δ功率和较低体温的非快速动眼睡眠）。

PFCS^st-GABA末端在筑巢和睡眠期间具有增强的活动，在LPO下丘脑和LH的不同细胞中诱导抑制性突触后电流。PFC也可能在没有过度疲劳的情况下决定睡眠状态。这些发现表明，PFC调控下丘脑以确保在合适的地方产生最佳睡眠。

据介绍，前额叶皮层是哺乳动物能够通过适当行动对包括内部状态在内情况做出反应的基础。其中一种内部状态可能是“疲倦”。

附：英文原文

Title: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

Author: Tossell, Kyoko, Yu, Xiao, Giannos, Panagiotis, Anuncibay Soto, Berta, Nollet, Mathieu, Yustos, Raquel, Miracca, Giulia, Vicente, Mikal, Miao, Andawei, Hsieh, Bryan, Ma, Ying, Vyssotski, Alexei L., Constandinou, Tim, Franks, Nicholas P., Wisden, William

Issue&Volume: 2023-09-21

Abstract: The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state could be ‘tiredness’. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFCSst-GABA) cells that responded to sleep deprivation. These cells projected to the lateral preoptic (LPO) hypothalamus and the lateral hypothalamus (LH). Stimulating PFCSst-GABA terminals in the LPO hypothalamus caused sleep-preparatory behavior (nesting, elevated theta power and elevated temperature), and stimulating PFCSst-GABA terminals in the LH mimicked recovery sleep (non-rapid eye-movement sleep with higher delta power and lower body temperature). PFCSst-GABA terminals had enhanced activity during nesting and sleep, inducing inhibitory postsynaptic currents on diverse cells in the LPO hypothalamus and the LH. The PFC also might feature in deciding sleep location in the absence of excessive fatigue. These findings suggest that the PFC instructs the hypothalamus to ensure that optimal sleep takes place in a suitable place.

DOI: 10.1038/s41593-023-01430-4

Source: https://www.nature.com/articles/s41593-023-01430-4

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex