小柯机器人

德国再生生物学与医学研究所Yuval Rinkevich团队近期取得重要工作进展，他们研究发现，CD201⁺筋膜祖细胞能够指导损伤修复。相关研究成果2023年11月15日在线发表于《自然》杂志上。

据了解，最佳的组织恢复和组织存活是通过组织炎症、收缩和疤痕形成的时空调节来实现的。

研究人员鉴定了一种多能成纤维细胞祖细胞，其在皮肤最深的结缔组织层筋膜中表达CD201。使用小鼠皮肤损伤模型、单细胞转录组学和遗传谱系追踪、消融和基因缺失模型，研究人员证明CD201⁺祖细胞通过产生多种特化的细胞类型来控制伤口愈合的速度，从促炎成纤维细胞到肌成纤维细胞，以时空调节的序列。研究人员确定视黄酸和缺氧信号是进入促炎和肌成纤维细胞状态的入口检查点。调节CD201⁺祖细胞分化损害成纤维细胞的时空形态和慢性延迟伤口愈合。

总之，促炎和肌成纤维细胞祖细胞及其分化途径的发现为理解和临床治疗受损伤口愈合提供了新的路线图。

附：英文原文

Title: CD201+ fascia progenitors choreograph injury repair

Author: Correa-Gallegos, Donovan, Ye, Haifeng, Dasgupta, Bikram, Sardogan, Aydan, Kadri, Safwen, Kandi, Ravinder, Dai, Ruoxuan, Lin, Yue, Kopplin, Robert, Shenai, Disha Shantaram, Wannemacher, Juliane, Ichijo, Ryo, Jiang, Dongsheng, Strunz, Maximilian, Ansari, Meshal, Angelidis, Illias, Schiller, Herbert B., Voltz, Thomas, Machens, Hans-Gnther, Rinkevich, Yuval

Issue&Volume: 2023-11-15

Abstract: Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.

DOI: 10.1038/s41586-023-06725-x

Source: https://www.nature.com/articles/s41586-023-06725-x

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html