小柯机器人

中国科学技术大学Zhi Zhang等研究人员合作发现，躯体感觉皮层和中央杏仁核通过向脾脏的迷走神经投射调节神经性疼痛介导的外周免疫反应。2024年1月30日，国际知名学术期刊《自然—神经科学》在线发表了这一成果。

研究人员发现急性和慢性神经病理性疼痛雄性小鼠脾脏T辅助细胞2（T_H2）免疫细胞反应受到不同程度的调节，迷走神经背运动核（ACh^DMV）的乙酰胆碱能神经元直接支配脾脏。结合体内记录和免疫细胞图谱分析发现，疼痛介导的外周T_H2免疫反应涉及以下两个不同的回路：初级体感皮层的谷氨酸能神经元（Glu^S1HL）→ACh^DMV→脾脏回路和杏仁核中央核的GABA能神经元（GABA^CeA）→ACh^DMV→脾脏回路。

急性疼痛状态会增加Glu^S1HL神经元对脾脏投射的ACh^DMV神经元的兴奋，并增加脾脏T_H2免疫细胞的比例。慢性疼痛状态会增加GABA^CeA神经元对脾脏投射的ACh^DMV神经元的抑制，并减少脾脏T_H2免疫细胞。因此，这项研究证明了大脑是如何编码脾脏中疼痛状态特异性免疫反应的。

据介绍，疼痛涉及神经免疫互作，但其机制仍不清楚。

附：英文原文

Title: Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Author: Zhu, Xia, Huang, Ji-Ye, Dong, Wan-Ying, Tang, Hao-Di, Xu, Si, Wu, Qielan, Zhang, Huimin, Cheng, Ping-Kai, Jin, Yuxin, Zhu, Meng-Yu, Zhao, Wan, Mao, Yu, Wang, Haitao, Zhang, Yan, Wang, Hao, Tao, Wenjuan, Tian, Yanghua, Bai, Li, Zhang, Zhi

Issue&Volume: 2024-01-30

Abstract: Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chronic neuropathic pain and that acetylcholinergic neurons in the dorsal motor nucleus of the vagus (AChDMV) directly innervate the spleen. Combined in vivo recording and immune cell profiling revealed the following two distinct circuits involved in pain-mediated peripheral TH2 immune response: glutamatergic neurons in the primary somatosensory cortex (GluS1HL)→AChDMV→spleen circuit and GABAergic neurons in the central nucleus of the amygdala (GABACeA)→AChDMV→spleen circuit. The acute pain condition elicits increased excitation from GluS1HL neurons to spleen-projecting AChDMV neurons and increased the proportion of splenic TH2 immune cells. The chronic pain condition increased inhibition from GABACeA neurons to spleen-projecting AChDMV neurons and decreased splenic TH2 immune cells. Our study thus demonstrates how the brain encodes pain-state-specific immune responses in the spleen.

DOI: 10.1038/s41593-023-01561-8

Source: https://www.nature.com/articles/s41593-023-01561-8

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex