小柯机器人

荷兰阿姆斯特丹大学Cyriel M. A. Pennartz研究小组揭示小鼠初级视觉皮层的视觉、听觉和运动处理三重分离。该项研究成果于2024年2月2日在线发表在《自然—神经科学》杂志上。

研究人员表示，初级感觉皮层会对跨模态刺激做出反应，例如，初级视觉皮层（V1）会出现听觉反应。然而，这些反应反映的是感觉输入还是通过声音诱发的身体运动进行的行为调节，目前仍不清楚。

研究人员发现，清醒小鼠V1中的声音诱发活动可分为听觉成分和行为成分，它们具有不同的时空轮廓，从而解决了这一争议。听觉成分开始于大约27毫秒，存在于浅层和深层，源自听觉皮层。声音诱发的口面部运动与大约80-100毫秒开始的V1神经活动相关，并解释了听觉频率调谐。视觉、听觉和运动活动表现为不同的神经层剖面和大体分离的神经元亚群。

在同时进行的视听刺激中，视觉表征与听觉相关活动和运动相关活动仍然是分离的。听觉、运动和视觉处理的这种三重分离性对于理解视觉皮层的不同输入如何相互作用以支持视觉至关重要。

附：英文原文

Title: Triple dissociation of visual, auditory and motor processing in mouse primary visual cortex

Author: Oude Lohuis, Matthijs N., Marchesi, Pietro, Olcese, Umberto, Pennartz, Cyriel M. A.

Issue&Volume: 2024-02-02

Abstract: Primary sensory cortices respond to crossmodal stimuli—for example, auditory responses are found in primary visual cortex (V1). However, it remains unclear whether these responses reflect sensory inputs or behavioral modulation through sound-evoked body movement. We address this controversy by showing that sound-evoked activity in V1 of awake mice can be dissociated into auditory and behavioral components with distinct spatiotemporal profiles. The auditory component began at approximately 27ms, was found in superficial and deep layers and originated from auditory cortex. Sound-evoked orofacial movements correlated with V1 neural activity starting at approximately 80–100ms and explained auditory frequency tuning. Visual, auditory and motor activity were expressed by different laminar profiles and largely segregated subsets of neuronal populations. During simultaneous audiovisual stimulation, visual representations remained dissociable from auditory-related and motor-related activity. This three-fold dissociability of auditory, motor and visual processing is central to understanding how distinct inputs to visual cortex interact to support vision.

DOI: 10.1038/s41593-023-01564-5

Source: https://www.nature.com/articles/s41593-023-01564-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex