直播回放|北京大学席鹏教授详解超分辨
2021-09-24 10:32
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直播时间:9月24日(周五)20:00——21:30(北京时间)

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2021年9月24日晚 8:00(北京时间),大家期待已久的 iCANX Talks第70期即将重磅来袭,本期直播我们有幸邀请到北京大学的席鹏教授来到iCANX Talks讲座系列,敬请期待!

The highly expected iCANX Talks Vol.70 will be ceremoniously holed at 8:00 pm of September 24 (Beijing time). This time, we are fortunate to invite5 Professor Peng Xi from Peking University to the iCANX Talks lecture series. so stay tuned!

在前面69期iCANX Talks直播中,累计收看观众已经达到千万人次,受到了国内外专家学者的普遍好评和追捧,目前,iCANX Talks已经成为极具国际影响力的高科技云端学术峰会。

In the previous 69 weeks iCANX talks , it totally attracted close to 10 million audiences worldwide. iCANX has been highlighted by experts and audiences globally. Now, iCANX Talks already becomes a well-known and popular international high-tech online event.

话不多说,先让小艾给大家详细介绍重磅嘉宾及演讲内容吧!

Here comes the abstracts & Bios of today’s iCANX Talks!

报告介绍

Super-resolution: an adventure on a new dimension

超分辨:以新维度,探新认知

Peng Xi

席鹏

Peking University

北京大学

Abstract

Super-resolution microscopy can attain unprecedented spatial resolution for the study of biological interactions. Here I will present two developments on the polarization-based structured illumination microscopy: (1) We developed polarized structured illumination microscopy (pSIM), which achieves super-resolution imaging of dipoles by interpreting the dipoles in spatio-angular hyperspace. We demonstrate the application of pSIM on a series of biological filamentous systems, such as cytoskeleton networks and λ-DNA, and report the dynamics of short actin sliding across a myosin-coated surface. Moreover, pSIM reveals the side-by-side organization of the actin ring structures in the membrane-associated periodic skeleton of hippocampal neurons. (2) We further report Spectrum and Polarization Optical Tomography (SPOT) technique to study the subcellular lipidomics in live cells. Simply using one single dye that universally stains lipid membranes, SPOT can simultaneously resolve the membrane morphology, polarity, and phase from the three optical-dimensions of intensity, spectrum, and polarization, respectively. These high-throughput optical properties reveal lipid heterogeneities of ten subcellular compartments, at different developmental stages, even within the same organelle.

超分辨显微镜可以通过前所未有的空间分辨率来研究生物相互作用。在这里,我将介绍基于偏振的结构照明显微成像技术的两个进展:(1)我们开发了偏振结构照明显微镜(pSIM),它通过解析空间角度超空间中的偶极子来实现偶极子超分辨率成像。我们展示了pSIM在一系列生物系统中的应用,如细胞骨架网络和λ-DNA,以及短肌动蛋白-肌球蛋白相互作用动力学。此外,pSIM揭示了海马神经元膜相关周期性骨架中,肌动蛋白环结构的并排组装。(2) 我们进一步报道了光谱和偏振光学层析(SPOT)技术来研究活细胞中的亚细胞脂质组学。SPOT只需使用一种普遍染色脂膜的单一染料,就可以分别从强度、光谱和偏振三个光学维度同时解析脂膜的形态、极性和相位。这些高通量光学特性揭示了10种亚细胞器在不同发育阶段,甚至在同一细胞器内的脂质异质性。

Biography

Dr. Peng Xi is a professor in College of Future Technology, Peking University, China. His research interest is focused on research and development of optical super-resolution microscopy techniques. He has published over 70 scientific papers in peer-reviewed journals including Nature, Nature Methods, Light, etc., and holds 19 issued invention patents, including 4 US patents. He is elected as a senior member of OSA since 2015. In 2020, he was awarded the NSFC National Outstanding Young Scholar. He is currently on the editorial board of 5 SCI-indexed journals such as Light: Science and Applications and Advanced Photonics. He has been invited to give over 50 invited talks in international conferences hosted by OSA and SPIE. He is also the Managing editor for Light: Science and Applications Beijing Office, in responsible for the News and Views section of the journal.

席鹏,北京大学未来技术学院教授,国家杰出青年基金获得者。主要从事超分辨显微成像技术的研究。在Nature, Nature Methods等国际一流期刊发表SCI收录期刊论文70余篇,总影响因子大于450,被引超过4000次。现担任Light: Science and Applications和Advanced Photonics等五份SCI收录国际学术期刊的编委。2016年获得中国光学重要成果奖。已授权美国专利4项,中国专利17项,编辑专著2部。担任Focus On Microscopy 组织国际学术顾问,美国光学学会高级会员(Senior Member)、美国光学学会成像光学设计技术组组长(2016-2019)等学术兼职。他还是《Light: Science and Applications》北京办事处的责任编辑,负责该杂志的新闻和观点部分。

Keywords

Super-resolution 超分辨

Polarized structured illumination 偏振结构照明显微镜

Spectrum and Polarization Optical Tomography 光谱和偏振光学层析

同时,本次讲座也邀请了来自澳大利亚国立大学的Chennupati Jagadish教授带来精彩的主持。来自悉尼科技大学杰出教授和南方科技大学讲席教授金大勇,新加坡国立大学的洪明辉教授担任嘉宾。以及来自悉尼科技大学的鲍国臣博士担任X挑战者。精彩不断,敬请期待!iCANX将继续努力,为科学交流服务,提供一个全球学术交流的顶级平台,敬请大家期待!

At the same time, this lecture also invited Professor Chennupati Jagadish from Australian National University to bring a wonderful host. Distinguished professor Dayong Jin at the University of Technology Sydney and a Chair Professor at Southern University of Science and Technology, and professor Minghui Hong from National University of Singapore as guests. And Guochen Bao from University of Technology Sydney as X-challenger. iCANX will continue to work hard to serve scientific exchanges and provide a top platform for global academic exchanges. Please look forward to it!

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