博文
科学家 Kathleen Gould （细胞生物学）
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科研学术生涯：
http://f1000biology.com/about/biography/439926051458668
研究团队与实验室：
http://www.mc.vanderbilt.edu/vumcdept/cellbio/gould/
发表的论文与研究成果：
http://www.mc.vanderbilt.edu/vumcdept/cellbio/gould/Pubs.html
since 2006
Bohnert, K.A., Chen, J.-S., Clifford, D.M., VanderKooi, C.W. and Gould, K.L. (2009) A Link between Aurora Kinase and Clp1/Cdc14 Regulation Uncovered by the Identification of a Fission Yeast Borealin-like Protein. Mol. Biol.Cell, 20, 3646-3659.
Roberts-Galbraith, R.H., Chen, J.-S., Wang, J., and Gould, K.L. (2009) The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring. J. Cell. Biol. 184(1): 113-127
Roberts-Galbraith, R.H. and Gould, K.L. (2008) Stepping into the ring: the SIN takes on contractile ring assembly. Genes Dev. 22(22): 3205-3216
Chen, C.T., Feoktistova, A., Chen, J.-S., Shim, Y.S., Clifford, D.M., Gould, K.L., and McCollum, D., (2008) The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1. Current Biol. 18(20): 1594-1599
Sczaniecka, M., Feoktistova, A., May, K.M., Chen, J.-S., Blyth, J., Gould, K.L., and Hardwick, K.G. The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). J. Biol. Chem. 283(34): 23039-47.
Clifford, D.M., Chen, C.T., Roberts-Galbraith, R.H., Feoktistova, A., Wolfe, B.A., Chen, J.-S., McCollum, D., Gould, K.L. (2008) The role of Cdc14 phosphatases in the control of cell division. Biochem. Soc. Trans. 36(Pt 3): 436-8
Clifford, D.M., Wolfe, B.A., Roberts-Galbraith, R.H., McDonald, W.H., Yates, J.R., Gould, K.L. (2008) The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1. J Cell Biol. 181(1): 79-88
Ohi, M.D., Feoktistiva, A., Ren, L., Yip, C., Cheng, Y., Chen J.-S., Yoon, H.J., Wall, J.S., Huang, Z., Penczek, P.A., Gould, K.L. and Walz, T. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell. 2007 Dec 14;28(5):871-85.
Ohi, M.D., Ren, L., Wall, J.S., Gould, K.L., and Walz, T. (2007) Structural characterization of the fission yeast U5U2/U6 spliceosome complex. PNAS USA 104(9): 3195-3200
Yoon, H.-J., Feoktistova, A., Wolfe, B. A., Jennings, J.L., Link, A.J., and Gould, K.L. (2006) Role of Hcn1 and its phosphorylation in fission yeast APC/C function. J. Biol. Chem. 281(43):32284-93
Wolfe, B.A., McDonald, W.H., Yates, Jr., J.R., and Gould, K.L. (2006) Phosphorylation-dependent regulation of the Cdc14/Clp1 phosphatase delays mitotic events in S. pombe. Dev.Cell 11:423-430
Rosenberg, J.A., Tomlin, G.C., McDonald, W.H., Snydsman, B.E., Muller, E.G., Yates, J.R. 3rd, Gould, K.L. (2006) Ppc89 Links Multiple Proteins, Including the Septation Initiation Network, to the Core of the Fission Yeast Spindle-Pole Body. Mol. Biol.Cell 17(9):3793-805
Mehta, S. and Gould, K.L. (2006) Identification of functional domains within the SIN kinase Cdc7. J. Biol. Chem. 281(15):9935-41
Vander Kooi, C.W., Ohi, M.D., Rosenberg, J.A., Oldham, M.L., Newcomer, M.E., Gould, K.L., Chazin, W.J. (2006) The Prp19 U-box Crystal Structure Suggests a Common Dimeric Architecture for a Class of Oligomeric E3 Ubiquitin Ligases. Biochemistry 45(1):121-130
部分名著与科研绩效：
K Burridge, K Fath, T Kelly, G Nuckolls, … - Annual review of cell …, 1988 - Annual Reviews
... the Extracellular Matrix and the Cytoskeleton Keith Burridge, Karl Fath, Thomas Kelly, Glen
Nuckolls, and Christopher Turner Department of Cell Biology and Anatomy, CB # 7090, 108 Swing
Building, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 ...
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1 Ludwig Institute for Cancer Research, Royal Free and University College School of
Medicine, London W1W 7BS, UK. 2 Departments of Microbiology and Biomedical
Engineering, Cardiovascular Research Center and Mellon Prostate Cancer Research ...
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Many observations suggest the presence of transmembrane linkages between the cytoskeleton
and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal
a co-alignment between actin filaments at the cell surface and extracellular fibronectin ...
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Abstract. Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress
fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, AJ, and A.
Hall, 1992. Cell. 70:389-399). The pathway by which rho triggers these events has not ...
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Abstract. Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal
adhesions, the regions where cells adhere to the underlying substra- tum. We have examined
the tyrosine phosphorylation of proteins in response to plating cells on extracellular matrix ...
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Many features of cell behavior are regulated by Rho family GTPases, but the most profound effects
of these proteins are on the actin cytoskeleton and it was these that first drew attention to this
family of signaling proteins. Focusing on Rho and Rac, we will discuss how their effectors ...
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276 Cell regulation bind Cdc42 [31*]. This targeting does require PAK binding to PIX (PAK interacting
exchange factor), a GEF for Rac [32*]. This suggests that there is a complex formed between
Rac or Cdc42; PAK (a downstream effector) and PIX (an upstream GEF). Mutations that ...
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Abstract. A number of cytoskeletal-associated pro- teins that are concentrated in focal
contacts, namely ot-actinin, vinculin, talin, and integrin, have been shown to interact in vitro such
that they suggest a potential link between actin filaments and the mem- brane. Because ...
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Antibodies specific for the skeletal muscle structural protein α-actinin are used to localize this
protein by indirect immunofluorescence in nonmuscle cells. In cultured nonmuscle cells, α-actinin
is localized along or between actin filament bundles producing an almost regular ...
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Abstract. The 68-kD protein (paxillin) is a cytoskele- tal component that localizes to the focal adhesions
at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal adhesions
of Madin-Darby bovine kidney (MDBK) epithelial cells but is absent, like talin, from the ...
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上一篇：科学家 Burridge, Keith （细胞生物学）
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