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耳聋基因研究动态与知识发现

已有 2209 次阅读 2011-1-28 15:14 |个人分类:知识发现|系统分类:论文交流|关键词:学者| 英国, 美国, 科学家, 科学院, 核糖核酸

PNAS:科学家揭开耳聋基因变异分子机制
英国科学家最近发表在美国《国家科学院院刊》(PNAS)上的一份研究报告称,小核糖核酸miR-96发生变异,可导致渐进性失聪。该分子机制的发现为改善听力损失和失聪的治疗手段奠定了基础。
Researchers reveal function of novel molecule that underlies human deafness http://www.physorg.com/news/2011-01-reveal-function-molecule-underlies-human.html miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells

http://www.pnas.org/content/early/2011/01/13/1016646108.abstract

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=9081

Start A-Literature C-Literature B-list Filter Literature
A-query: deafness
C-query: miR-96
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 3 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 9081 and can be accessed from the start page after you leave this session. There are 253 terms on the current B-list (59 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 9081 started Fri Jan 28 02:45:19 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
9081 Search ARROWSMITH A
A_query_raw: deafnessFri Jan 28 02:45:40 2011

A query = deafness started Fri Jan 28 02:45:42 2011
A query resulted in 30064 titles
9081 Search ARROWSMITH C
C_query_raw: miR-96 Fri Jan 28 02:46:00 2011

C: miR-96 37

A: pubmed_query_A 30064

AC: ( deafness ) AND ( miR-96 ) 3

C query = miR-96 started Fri Jan 28 02:46:00 2011
C query resulted in 37 titles
A AND C query resulted in 3 titles
253 B-terms ready on Fri Jan 28 02:47:55 2011

B-list on Fri Jan 28 02:51:06 2011
1 microrna
2 model retinal degeneration
3 outer hair cell
4 expression profiling
5 retinitis pigmentosa
6 responsible nonsyndromic
7 expression profile
8 hearing
9 retinal degeneration
10 retinitis
11 hearing loss
12 real time pcr
13 cochlear inner
14 mammalian cochlear
15 ear development
16 hair cell
17 nonsyndromic
18 cochlear
19 differentially expressed
20 transcriptome
21 sensorineural
22 expression pattern
23 inner ear
24 development inner ear
25 progressive hearing loss
26 model retinal
27 inner outer hair
28 mouse model
29 neural crest
30 mirna
31 osteogenesis
32 tumor suppressor gene
33 1b
34 tumor suppressor
35 ear
36 pigmentosa
37 chronic myeloid leukemia
38 urothelial
39 oncogene
40 chronic myeloid
41 mutation
42 transcriptional
43 pcr
44 outer
45 mouse retina
46 degeneration
47 gene mutation
48 down regulation
49 hodgkin
50 myeloid leukemia
51 sensory
52 progressive hearing
53 polymorphism
54 dorsal root
55 gene
56 inner
57 real time
58 hepatocellular
59 loud



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