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整合素与中性粒细胞研究动态与基因知识发现

已有 2662 次阅读 2011-1-29 12:25 |个人分类:知识发现|系统分类:论文交流|关键词:学者

整合素信号调控中性粒细胞极性
国际知名期刊《免疫》(Immunity)近期发表了华东师大生命科学研究院生命医学研究所教授王平与美国耶鲁大学教授Dan Wu合作的最新研究成果“整合素诱导的PIP5K1C激酶的极化调控中性粒细胞极性、方向选择及渗出”。
东师大教授王平:找到了炎症的新机制
华东师范大学生命科学研究院生命医学研究所王平教授和美国耶鲁大学的吴殿卿教授合作的最新研究成果“整合素诱导的PIP5K1C激酶对中粒性细胞到达炎症部位具有调控机制”发表在了国际知名学术期刊《免疫》(Immunity)上,该研究成果揭示了导致白细胞中最重要的中性粒细胞渗出血管,并定向迁移到炎症部位的关键因素在哪里,又是如何发挥作用的。
Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration

http://www.cell.com/immunity/abstract/S1074-7613(10)00320-1#aff2

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature
A-query: Integrin
C-query: Neutrophil
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 4276 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 14106 and can be accessed from the start page after you leave this session. There are 2788 terms on the current B-list (26 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 14106 started Fri Jan 28 23:55:04 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
14106 Search ARROWSMITH A
A_query_raw: IntegrinFri Jan 28 23:55:27 2011

A query = Integrin started Fri Jan 28 23:55:27 2011
A query resulted in 48186 titles
14106 Search ARROWSMITH C
C_query_raw: Neutrophil Fri Jan 28 23:55:59 2011

C: Neutrophil 107130

A: pubmed_query_A 48186

AC: ( Integrin ) AND ( Neutrophil ) 4276

C query = Neutrophil started Fri Jan 28 23:56:00 2011
C query resulted in 50000 titles
A AND C query resulted in 4276 titles
52989 B-terms ready on Sat Jan 29 00:06:52 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
2788 B-terms left after filter executed Sat Jan 29 00:43:50 2011

2788 B-terms left after filter executed Sat Jan 29 00:44:14 2011

B-list on Sat Jan 29 00:46:49 2011
1 cox-2
2 nod2
3 adiponectin
4 toll receptor
5 rankl
6 stat5
7 cd86
8 jnk
9 wnt
10 tlr4
11 c ebp
12 jak2
13 smad3
14 ccaat enhancer binding
15 paxillin
16 akt
17 vegf
18 caspase-8
19 nod scid
20 angiopoietin
21 mtor
22 cd38
23 stat3
24 erk1
25 adenovirus mediated gene
26 ikappab



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