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诺奖得主科比尔卡的科学贡献和学术影响力
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Brian K. Kobilka
Publications: 167 | Citations: 6495 | G-Index: 78 | H-Index: 43
| The information is calculated based on the tens of millions of scholarly articles currently discoverable within Microsoft Academic Search. As more content gets indexed, the accuracy and completeness will continue to improve. | ||
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Collaborated with 550 co-authors from 1979 to 2012; Cited by 13325 authors
| 找到的结果数: | 304 |
 | |
| 被引频次总计: | 24803 |
| 去除自引的被引频次总计: | 23780 |
| |
| 施引文献: | 14127 |
| 去除自引的施引文献: | 13929 |
| |
| 每项平均引用次数: | 81.59 |
| |
| h-index : | 82 |
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字段: 作者 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| KOBILKA BK | 225 | 74.013 % |  | ||
| KOBILKA B | 78 | 25.658 % | | ||
| LEFKOWITZ RJ | 33 | 10.855 % | | ||
| CARON MG | 30 | 9.868 % | | ||
| BERNSTEIN D | 29 | 9.539 % | | ||
| HEIN L | 27 | 8.882 % | | ||
| SEIFERT R | 24 | 7.895 % | | ||
| GETHER U | 22 | 7.237 % | | ||
| KOBILKA TS | 20 | 6.579 % | | ||
| RASMUSSEN SGF | 20 | 6.579 % | |
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字段: 国家/地区 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| USA | 299 | 98.355 % | | ||
| FINLAND | 15 | 4.934 % | | ||
| DENMARK | 13 | 4.276 % | | ||
| GERMANY | 12 | 3.947 % | | ||
| ENGLAND | 7 | 2.303 % | | ||
| FRANCE | 6 | 1.974 % | | ||
| SPAIN | 6 | 1.974 % | | ||
| BELGIUM | 4 | 1.316 % | | ||
| SOUTH KOREA | 4 | 1.316 % | |
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字段: 基金资助机构 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| NATIONAL INSTITUTES OF HEALTH | 16 | 5.263 % | | ||
| LUNDBECK FOUNDATION | 11 | 3.618 % | | ||
| MATHERS FOUNDATION | 11 | 3.618 % | | ||
| EUROPEAN COMMUNITY | 5 | 1.645 % | | ||
| NATIONAL SCIENCE FOUNDATION | 5 | 1.645 % | | ||
| NIH | 5 | 1.645 % | | ||
| UNIVERSITY OF MICHIGAN | 5 | 1.645 % | | ||
| MATHER CHARITABLE FOUNDATION | 4 | 1.316 % | | ||
| DANISH NATIONAL RESEARCH COUNCIL | 3 | 0.987 % | | ||
| EDICT CONSORTIUM | 3 | 0.987 % | | ||
| INSTITUTE FOR THE ENCOURAGEMENT OF SCIENTIFIC RESEARCH AND INNOVATION OF BRUSSELS ISRIB | 3 | 0.987 % | | ||
| STANFORD MEDICAL SCIENTIST TRAINING PROGRAM | 3 | 0.987 % | | ||
| FP7 COST ACTION | 2 | 0.658 % | | ||
| FUND FOR SCIENTIFIC RESEARCH OF FLANDERS FWO VLAANDEREN | 2 | 0.658 % | | ||
| INSERM | 2 | 0.658 % | | ||
| NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES NIGMS | 2 | 0.658 % | | ||
| NATIONAL INSTITUTE OF NEURAL DISORDERS AND STROKE | 2 | 0.658 % | | ||
| NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE | 2 | 0.658 % | | ||
| SCIENCE FOUNDATION IRELAND | 2 | 0.658 % | |
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字段: 组织扩展 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| Stanford Univ | 259 | 85.197 % | | ||
| DUKE UNIV | 37 | 12.171 % | | ||
| Duke Univ | 37 | 12.171 % | | ||
| Univ Calif System | 20 | 6.579 % | | ||
| Univ Turku | 14 | 4.605 % | | ||
| Univ Copenhagen | 12 | 3.947 % | | ||
| Univ East Finland | 11 | 3.618 % | | ||
| Univ Wurzburg | 11 | 3.618 % | | ||
| HOWARD HUGHES MED INST | 10 | 3.289 % | | ||
| Univ Michigan | 9 | 2.961 % | | ||
| NIA | 8 | 2.632 % | | ||
| Univ Wisconsin System | 8 | 2.632 % | | ||
| Univ Autonoma Barcelona | 6 | 1.974 % | | ||
| Vanderbilt Univ | 6 | 1.974 % | | ||
| Yale Univ | 6 | 1.974 % | | ||
| Imperial Coll London | 5 | 1.645 % | | ||
| Mt Sinai Sch Med | 4 | 1.316 % | | ||
| STANFORD MED CTR | 4 | 1.316 % | | ||
| Vrije Univ Brussels | 4 | 1.316 % | | ||
| Columbia Univ | 3 | 0.987 % | | ||
| DE SHAW RES | 3 | 0.987 % | | ||
| HARVARD UNIV | 3 | 0.987 % | | ||
| Hanyang Univ | 3 | 0.987 % | | ||
| Harvard Univ | 3 | 0.987 % | | ||
| MERCK SHARP DOHME RES LABS | 3 | 0.987 % | |
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字段: 出版年 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| 1998 | 30 | 9.868 % | | ||
| 1997 | 24 | 7.895 % | | ||
| 2002 | 23 | 7.566 % | | ||
| 2007 | 18 | 5.921 % | | ||
| 1999 | 15 | 4.934 % | | ||
| 2012 | 15 | 4.934 % | | ||
| 1988 | 13 | 4.276 % | | ||
| 2001 | 13 | 4.276 % | | ||
| 2003 | 13 | 4.276 % | | ||
| 2000 | 12 | 3.947 % | | ||
| 1995 | 11 | 3.618 % | | ||
| 1992 | 10 | 3.289 % | | ||
| 1993 | 10 | 3.289 % | | ||
| 1996 | 10 | 3.289 % | | ||
| 1987 | 9 | 2.961 % | | ||
| 2004 | 9 | 2.961 % | | ||
| 2005 | 9 | 2.961 % | | ||
| 2011 | 9 | 2.961 % | | ||
| 1994 | 8 | 2.632 % | | ||
| 2008 | 8 | 2.632 % | | ||
| 2006 | 7 | 2.303 % | | ||
| 2010 | 7 | 2.303 % | | ||
| 2009 | 5 | 1.645 % | | ||
| 1986 | 4 | 1.316 % | | ||
| 1989 | 4 | 1.316 % | | ||
| 1990 | 3 | 0.987 % | | ||
| 1991 | 3 | 0.987 % | |
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字段: 研究方向 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| BIOCHEMISTRY MOLECULAR BIOLOGY | 93 | 30.592 % | | ||
| PHARMACOLOGY PHARMACY | 53 | 17.434 % | | ||
| SCIENCE TECHNOLOGY OTHER TOPICS | 51 | 16.776 % | | ||
| CARDIOVASCULAR SYSTEM CARDIOLOGY | 35 | 11.513 % | | ||
| CELL BIOLOGY | 34 | 11.184 % | | ||
| NEUROSCIENCES NEUROLOGY | 18 | 5.921 % | | ||
| CHEMISTRY | 17 | 5.592 % | | ||
| LIFE SCIENCES BIOMEDICINE OTHER TOPICS | 15 | 4.934 % | | ||
| RESEARCH EXPERIMENTAL MEDICINE | 15 | 4.934 % | | ||
| BIOPHYSICS | 14 | 4.605 % | | ||
| PHYSIOLOGY | 10 | 3.289 % | | ||
| BIOTECHNOLOGY APPLIED MICROBIOLOGY | 5 | 1.645 % | | ||
| GENERAL INTERNAL MEDICINE | 5 | 1.645 % | | ||
| ANESTHESIOLOGY | 4 | 1.316 % | | ||
| PEDIATRICS | 4 | 1.316 % | | ||
| HEMATOLOGY | 3 | 0.987 % | | ||
| ENDOCRINOLOGY METABOLISM | 2 | 0.658 % | | ||
| GENETICS HEREDITY | 2 | 0.658 % | | ||
| ZOOLOGY | 2 | 0.658 % | |
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字段: 来源出版物 | 记录 计数 | %，共 304 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| JOURNAL OF BIOLOGICAL CHEMISTRY | 38 | 12.500 % | | ||
| CIRCULATION | 22 | 7.237 % | | ||
| NATURE | 19 | 6.250 % | | ||
| PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 19 | 6.250 % | | ||
| MOLECULAR PHARMACOLOGY | 17 | 5.592 % | | ||
| FASEB JOURNAL | 14 | 4.605 % | | ||
| NAUNYN SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 13 | 4.276 % | | ||
| CLINICAL RESEARCH | 12 | 3.947 % | | ||
| SCIENCE | 9 | 2.961 % | | ||
| TRENDS IN PHARMACOLOGICAL SCIENCES | 9 | 2.961 % | | ||
| AMERICAN JOURNAL OF PHYSIOLOGY HEART AND CIRCULATORY PHYSIOLOGY | 7 | 2.303 % | | ||
| ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 6 | 1.974 % | | ||
| BIOPHYSICAL JOURNAL | 5 | 1.645 % | | ||
| CRITICAL CARE MEDICINE | 5 | 1.645 % | | ||
| ANESTHESIOLOGY | 4 | 1.316 % | | ||
| BIOCHEMISTRY | 4 | 1.316 % | | ||
| EMBO JOURNAL | 4 | 1.316 % | | ||
| PEDIATRIC RESEARCH | 4 | 1.316 % | | ||
| ANALYTICAL BIOCHEMISTRY | 3 | 0.987 % | | ||
| BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 3 | 0.987 % | | ||
| BRITISH JOURNAL OF PHARMACOLOGY | 3 | 0.987 % | | ||
| JOURNAL OF NEUROSCIENCE | 3 | 0.987 % | | ||
| NEUROSCIENCE | 3 | 0.987 % | | ||
| BLOOD | 2 | 0.658 % | | ||
| CURRENT OPINION IN STRUCTURAL BIOLOGY | 2 | 0.658 % | | ||
| EUROPEAN JOURNAL OF BIOCHEMISTRY | 2 | 0.658 % | | ||
| HYPERTENSION | 2 | 0.658 % | | ||
| JOURNAL OF CLINICAL INVESTIGATION | 2 | 0.658 % | | ||
| JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 2 | 0.658 % | | ||
| MOLECULAR BIOLOGY OF THE CELL | 2 | 0.658 % | | ||
| MOLECULAR ENDOCRINOLOGY | 2 | 0.658 % | | ||
| NATURE CHEMICAL BIOLOGY | 2 | 0.658 % | | ||
| NATURE METHODS | 2 | 0.658 % | | ||
| NATURE STRUCTURAL MOLECULAR BIOLOGY | 2 | 0.658 % | | ||
| NEUROPHARMACOLOGY | 2 | 0.658 % | | ||
| TRENDS IN CARDIOVASCULAR MEDICINE | 2 | 0.658 % | |
Brian Kobilka，斯坦福大学医学院分子与细胞生理与医学系教授，美国国家科学院院士，以GPCRs结构生物学研究著称。2007年，Kobilka与科学家Raymond C. Stevens，利用T4溶菌酶融合蛋白方法解析了第一个非视紫红质GPCR晶体结构：人beta2肾上腺素受体，他还独立地通过抗体片段介导法解析了人beta2肾上腺素受体的结构。2011年，Kobilka研究组解析了结合激动剂的处于活性状态的人beta2肾上腺素受体的结构（Nature，2011，被引56次）。随后又解析Gαβγ-β2肾上腺素受体复合物的结构，完整解释了GPCRs如何被配体激活以及再激活下游G蛋白从而传递信号的过程。
GPCR（G Protein Coupled Receptor，即G蛋白偶联受体）广泛参与感知、生殖、发育、生长、神经和精神等多种生命活动以及内分泌和代谢等多种生理过程；与糖尿病、心脏病、肿瘤、免疫和感染性疾病、神经与精神疾病等重要疾病的发生、发展及治疗密切相关。超过50%的临床用药物以及正在研发中的药物都作用于GPCRs。全球20种最畅销的12种药物都是以GPCRs作用靶标，每年的销售总额高达2000亿美元。
G蛋白偶联受体的激活构型和多重构型
激动剂（Agonist）作用于细胞受体后，会显著改变受体的构象，从而将信息传递下去，这种与激动剂结合的受体构象通常被称为GPCR的激活构型。GPCR受体激活结构的获得主要存在两个方面的困难：第一，在G蛋白未与GPCR结合的情况下，受体与配体的亲和力较弱，并且配体解离的速度很快，很难捕捉到他们共存。第二，受体激活的构型相对于失活的构型非常不稳定，不利于结晶。为克服这些困难，Kobilka实验小组同时采用了共价修饰的b2肾上腺素能受体激动剂和应用羊驼产生的纳米抗体nanobody结合的方法，得到了激动剂结合的激活状态的受体结构，观察到跨膜螺旋发生了显著重构，以及受体的细胞第二内环变构为a螺旋(Rasmussen, Choi et al. 2011; Rosenbaum, Zhang et al. 2011)。在设法解析与激动剂结合的受体激活状态的同时，Kobilka实验小组应用荧光标记和核磁共振技术，Lefkowitz实验小组应用质谱解析技术，证明了多个不同的肾上腺素能受体的配体可以引起受体的多种不同构型(Yao, Parnot et al. 2006; Bokoch, Zou et al. 2010; Kahsai, Xiao et al. 2011)。
与诺奖得主科比尔卡面对面：一位真正的科学家
https://m.sciencenet.cn/blog-280034-654370.html
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